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Symbol
Name
ID
Pole
polymerase (DNA directed), epsilon
MGI:1196391
Phenotype annotations related to neoplasm
Darker colors indicate more annotations
Human Phenotypes
Colorectal polyposis
Hereditary nonpolyposis colorectal carcinoma
Colon cancer
Neoplasm of the stomach
Endometrial carcinoma
Uterine leiomyosarcoma
Renal cell carcinoma
Transitional cell carcinoma of the bladder
Disease(s) Associated with POLE
colorectal cancer

Mouse Phenotypes
increased intestinal adenocarcinoma incidence
increased colon adenocarcinoma incidence
increased small intestine adenocarcinoma incidence
increased intestinal adenoma incidence
increased adenoma incidence
increased lymphoma incidence
increased histiocytic sarcoma incidence
increased lung tumor incidence
increased tumor incidence
Availability Mouse Genotype
Poletm1.1Bdp/Poletm1.1Bdp

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory