|
Symbol Name ID |
Polg
polymerase (DNA directed), gamma MGI:1196389 |
| Darker colors indicate more annotations |
| Human Phenotypes | Abnormal vestibular function |
Sensorineural hearing impairment |
Bilateral sensorineural hearing impairment |
Hearing impairment |
| Disease(s) Associated with POLG | ||||
| autosomal dominant progressive external ophthalmoplegia 1 | ||||
| autosomal recessive progressive external ophthalmoplegia 1 | ||||
| mitochondrial DNA depletion syndrome 4b | ||||
| sensory ataxic neuropathy, dysarthria, and ophthalmoparesis |
| Mouse Phenotypes | cochlear outer hair cell degeneration |
cochlear hair cell degeneration |
stria vascularis degeneration |
increased or absent threshold for auditory brainstem response |
increased susceptibility to age-related hearing loss |
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| Availability | Mouse Genotype | |||||
| Polgtm1Prol/Polgtm1Prol | ||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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