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Symbol
Name
ID
Prss12
protease, serine 12 neurotrypsin (motopsin)
MGI:1100881
Phenotype annotations related to nervous system
Darker colors indicate more annotations
Human Phenotypes
Microcephaly
Postnatal microcephaly
Hypertonia
Spasticity
Delayed myelination
Lissencephaly
Pachygyria
Polymicrogyria
Cortical dysplasia
Large basal ganglia
Hypoplasia of the corpus callosum
Absent septum pellucidum
Cerebral atrophy
Megalencephaly
Cerebellar hypoplasia
EEG with focal epileptiform discharges
Multifocal epileptiform discharges
EEG with generalized epileptiform discharges
Hypsarrhythmia
Babinski sign
Cognitive impairment
Intellectual disability
Intellectual disability, mild
Intellectual disability, moderate
Intellectual disability, progressive
Intellectual disability, severe
Absent speech
Dysarthria
Echolalia
Incomprehensible speech
Poor speech
Hyperreflexia
Hyperactive deep tendon reflexes
Dyskinesia
Dystonia
Unsteady gait
Hyperactivity
Attention deficit hyperactivity disorder
Involuntary movements
Chorea
Myoclonus
Stereotypy
Recurrent hand flapping
Tremor
Aggressive behavior
Self-mutilation
Autistic behavior
Diminished ability to concentrate
Anxiety
Depressivity
Impulsivity
Short attention span
Sleep disturbance
Bruxism
Delayed speech and language development
Global developmental delay
Motor delay
Delayed ability to walk
Seizures
Epileptic spasms
Febrile seizures
Focal-onset seizure
Generalized-onset seizure
Disease(s) Associated with PRSS12
autosomal recessive non-syndromic intellectual disability

Mouse Phenotypes
abnormal dendritic spine morphology
abnormal neuron physiology
Availability Mouse Genotype
Prss12tm1Mits/Prss12tm1Mits

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory