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Symbol
Name
ID
Smad7
SMAD family member 7
MGI:1100518
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
immune system phenotype
increased B cell apoptosis
decreased B cell proliferation
decreased T cell proliferation
abnormal thymus morphology
thymus hypoplasia
abnormal class switch recombination
abnormal T-helper 1 cell differentiation
decreased activated T cell number
decreased interferon-gamma secretion
increased interferon-gamma secretion
decreased interleukin-10 secretion
decreased interleukin-17 secretion
decreased interleukin-9 secretion
decreased susceptibility to experimental autoimmune encephalomyelitis
increased susceptibility to experimental autoimmune encephalomyelitis
Availability Mouse Genotype
Smad7Gt(YHC053)Byg/Smad7Gt(YHC053)Byg
Smad7tm1Rheu/Smad7tm1Rheu
Tg(Cd2-Smad7)#Chbe/0
Smad7tm1.1Ink/Smad7tm1.1Ink
Tg(Cd4-cre)1Cwi/0  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory