Symbol
Name
ID

Npc1
NPC intracellular cholesterol transporter 1
MGI:1097712

Phenotype annotations related to behavior/neurological

Darker colors indicate more annotations

Mouse Phenotypes

abnormal object recognition memory

decreased exploration in new environment

impaired learning

decreased food intake

decreased anxiety-related response

abnormal response to novel object

abnormal motor capabilities/coordination/movement

increased startle reflex

tremors

ataxia

impaired balance

impaired coordination

decreased grip strength

increased grip strength

abnormal gait

decreased locomotor activity

increased locomotor activity

abnormal pain threshold

hypoalgesia

Availability

Mouse Genotype

Npc1^m1N/Npc1^m1N

Npc1^nmf164/Npc1^nmf164

Npc1^spm/Npc1^spm

Npc1^tm1.1Dso/Npc1^tm1.1Dso

Npc1^tm1.2Apl/Npc1^tm1.2Apl

Npc1^tm1Mbjg/Npc1^tm1Mbjg

Npc1^tm1Tacf/Npc1^tm1Tacf

Npc1^m1N/Npc1^tm1.2Apl

Npc1^{tm1b(EUCOMM)Hmgu}/Npc1⁺

Npc1^tm1Tacf/Npc1^tm2Tacf

Npc1^m1N/Npc1^tm1.1Apl
Tg(CAG-cre/Esr1*)5Amc/0 (conditional)

Npc1^m1N/Npc1^tm1.1Apl
Tg(Syn1-cre)671Jxm/0 (conditional)

Npc1^tm1.1Apl/Npc1^tm1.2Apl
Tg(Pcp2-cre)2Mpin/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23