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Symbol
Name
ID
Adam17
a disintegrin and metallopeptidase domain 17
MGI:1096335
Phenotype annotations related to hematopoietic system
Darker colors indicate more annotations

Mouse Phenotypes
enhanced leukocyte tethering or rolling
myeloid hyperplasia
extramedullary hematopoiesis
increased bone marrow cell number
increased erythrocyte cell number
decreased hematocrit
increased hemoglobin content
increased neutrophil cell number
thrombocytosis
decreased B cell number
increased T-helper 1 cell number
increased T-helper 17 cell number
increased T-helper 2 cell number
decreased T cell number
decreased lymphocyte cell number
increased macrophage cell number
increased leukocyte cell number
abnormal spleen morphology
increased spleen red pulp amount
enlarged spleen
increased IgE level
abnormal macrophage physiology
abnormal platelet physiology
Availability Mouse Genotype
Adam17tm1.1Srj/Adam17tm1.1Srj
Adam17tm1Imx/Adam17tm1Imx
Adam17tm1Rain/Adam17tm1Rain
Adam17tm1a(EUCOMM)Wtsi/Adam17+
Adam17tm1.2Bbl/Adam17tm1.2Bbl
Sox9tm3(cre)Crm/Sox9+  (conditional)
Adam17tm1Bbl/Adam17tm1Bbl
Lyz2tm1(cre)Ifo/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory