About   Help   FAQ
Symbol
Name
ID
Pten
phosphatase and tensin homolog
MGI:109583
Phenotype annotations related to neoplasm
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Lymphoma
Neoplasm of the breast
Breast carcinoma
Fibroadenoma of the breast
Capillary hemangioma
Visceral angiomatosis
Esophageal carcinoma
Hamartomatous polyposis
Intestinal polyposis
Neoplasm of the adrenal cortex
Thyroid adenoma
Hurthle cell thyroid adenoma
Thyroid carcinoma
Prostate cancer
Dysgerminoma
Ovarian carcinoma
Ovarian papillary adenocarcinoma
Uterine neoplasm
Bladder neoplasm
Transitional cell carcinoma of the bladder
Subcutaneous lipoma
Lipoma
Multiple lipomas
Meningioma
Neoplasm
Carcinoma
Disease(s) Associated with PTEN
Bannayan-Riley-Ruvalcaba syndrome
breast cancer
esophageal cancer
macrocephaly-autism syndrome
ovarian cancer
prostate cancer
urinary bladder cancer

Mouse Phenotypes
neoplasm
increased gastrointestinal tumor incidence
increased colon adenocarcinoma incidence
increased stomach tumor incidence
increased mammary gland tumor incidence
increased fibroadenoma incidence
increased mammary adenocarcinoma incidence
increased mammary adenoacanthoma incidence
increased mammary gland tumor incidence in breeding females
increased adrenal gland tumor incidence
increased pheochromocytoma incidence
increased granulosa cell tumor incidence
increased pancreatic ductal adenocarcinoma incidence
increased pancreatic intraepithelial neoplasia incidence
increased prostate gland tumor incidence
increased prostate gland adenocarcinoma incidence
increased prostate intraepithelial neoplasia incidence
increased T cell derived lymphoma incidence
increased thyroid tumor incidence
increased thyroid adenoma incidence
increased thyroid carcinoma incidence
decreased incidence of tumors by chemical induction
increased incidence of tumors by chemical induction
increased skin tumor incidence
increased skin hamartoma incidence
increased skin papilloma incidence
increased skin squamous cell carcinoma incidence
increased cholangiocarcinoma incidence
increased liver tumor incidence
increased hepatocellular carcinoma incidence
increased liver adenoma incidence
abnormal metastatic potential
increased metastatic potential
abnormal tumor susceptibility
abnormal tumor incidence
increased hamartoma incidence
increased hemangioma incidence
increased leukemia incidence
increased acute lymphoblastic leukemia incidence
increased T cell acute lymphoblastic leukemia incidence
increased acute promyelocytic leukemia incidence
increased lymphoma incidence
increased malignant tumor incidence
increased carcinoma incidence
increased lung adenocarcinoma incidence
increased endometrial carcinoma incidence
increased lung squamous cell carcinoma incidence
increased renal carcinoma incidence
increased spindle cell carcinoma incidence
increased squamous cell carcinoma incidence
increased urinary bladder carcinoma incidence
increased urinary bladder transitional cell carcinoma incidence
increased uterus carcinoma incidence
increased neurofibrosarcoma incidence
increased myoepithelioma incidence
increased papilloma incidence
increased teratoma incidence
increased incidence of tumors by ionizing radiation induction
increased urethra carcinoma incidence
decreased tumor incidence
increased tumor incidence
Availability Mouse Genotype
Ptentm1.1Mro/Ptentm1.1Mro
Ptentm1.1Gle/Pten+
Ptentm1.1Hwu/Pten+ !
Ptentm1.1Mro/Pten+
Ptentm1.2Mwst/Pten+
Ptentm1Hwu/Pten+ !
Ptentm1Mak/Pten+
Ptentm1Ppp/Pten+
Ptentm1Ppp/Ptentm2Ppp
Ptentm1Rps/Pten+
Ptentm2.1Gle/Pten+
Ptentm2Hwu/Pten+ !
Tg(Pten)1Srn/0
Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(S100a4-cre)1Gle/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)#Smr/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Gfap-cre)77.6Mvs/0  (conditional)
*
Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+
Ptentm1Hwu/Ptentm1Hwu  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Pdx1-cre)89.1Dam/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Nkx2-1-cre)2Sand/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Alb1-cre)1Dlr/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh16-cre)91Igr/0  (conditional)
*
Ptentm1Hwu/Ptentm1Hwu
Tg(MMTV-cre)7Mul/0  (conditional)
*
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Fabp1-cre)1Jig/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0  (conditional)
*
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu  (conditional)
Ptentm1Hwu/Ptentm1Hwu  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0  (conditional)
*
Ptentm1Hwu/Ptentm1Hwu
Amhr2tm3(cre)Bhr/Amhr2+  (conditional)
Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu  (conditional)
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(MMTV-cre)#Tfln/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Adipoq-cre)1Evdr/0  (conditional)
*
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)20Fwan/?  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Pgc-cre,-secNluc)#Hcz/0  (conditional)
Ptentm1Mro/Ptentm1Mro
Tg(En2-cre)22Alj/0  (conditional)
*
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Pbsn-cre)4Prb/0  (conditional)
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Pbsn-cre)8113ANg/0  (conditional)
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(TPO-cre)1Shk/0  (conditional)
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Osr1-cre)4Mrt/0  (conditional)
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Dhh-cre)1Mejr/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Gfap-cre)1Sbk/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Cyp1a1-cre)1Dwi/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Col2a1-cre)1Xya/?  (conditional)
Hprt1tm1(Pbsn*-cre/ERT2)Jir/Y
Ptentm2Mak/Ptentm2Mak  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Fabp1-cre)1Jig/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(KLK3-cre)13Saa/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(MMTV-cre)#Tfln/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Wap-cre)11738Mam/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Nes-cre/ERT2,-ALPP)1Sbk/0  (conditional)
*
Ptentm1Hwu/Pten+
Tg(KRT14-cre)#Smr/0  (conditional)
Ptentm1Hwu/Pten+
Tg(Pbsn-cre)4Prb/0  (conditional)
Ptentm1Hwu/Pten+
Tg(Nkx2-1-cre)2Sand/0  (conditional)
Ptentm1Mro/Pten+
Tg(KLK3-cre)D4Trp/0  (conditional)
Ptentm1Mro/Pten+
Tg(Pbsn-cre)4Prb/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/16/2024
MGI 6.23
The Jackson Laboratory