Symbol Name ID |
Pten
phosphatase and tensin homolog MGI:109583 |
Darker colors indicate more annotations |
Human Phenotypes | Subcutaneous hemorrhage |
Palmoplantar hyperkeratosis |
Gynecomastia |
Neoplasm of the breast |
Breast carcinoma |
Fibroadenoma of the breast |
Cutis marmorata |
Telangiectasia |
Coarse hair |
Cutis laxa |
Irregular hyperpigmentation |
Cafe-au-lait spot |
Multiple cafe-au-lait spots |
Subcutaneous lipoma |
Nevus |
Numerous nevi |
Acrokeratosis |
Subcutaneous nodule |
Skin tags |
Disease(s) Associated with PTEN | |||||||||||||||||||
Bannayan-Riley-Ruvalcaba syndrome | |||||||||||||||||||
breast cancer | |||||||||||||||||||
macrocephaly-autism syndrome | |||||||||||||||||||
ovarian cancer |
Mouse Phenotypes | abnormal branching of the mammary ductal tree |
abnormal involution of the mammary gland |
abnormal mammary gland growth during pregnancy |
abnormal mammary gland epithelium morphology |
mammary gland duct hyperplasia |
abnormal mammary gland lobule morphology |
abnormal nipple morphology |
increased mammary gland tumor incidence |
increased fibroadenoma incidence |
increased mammary adenocarcinoma incidence |
increased mammary adenoacanthoma incidence |
increased mammary gland tumor incidence in breeding females |
mammary gland hyperplasia |
ruffled hair |
abnormal hair shaft morphology |
hair follicle outer root sheath hyperplasia |
enlarged hair follicles |
abnormal vibrissa follicle morphology |
abnormal epidermal layer morphology |
hyperkeratosis |
acanthosis |
thick epidermis suprabasal layer |
epidermal hyperplasia |
thick epidermis |
flaky skin |
skin lesions |
wrinkled skin |
thick skin |
increased skin tumor incidence |
increased skin hamartoma incidence |
increased skin papilloma incidence |
increased skin squamous cell carcinoma incidence |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||
Ptentm1.1Gle/Pten+ | |||||||||||||||||||||||||||||||||
Ptentm1.1Hwu/Pten+ | |||||||||||||||||||||||||||||||||
Ptentm1.2Mwst/Pten+ | |||||||||||||||||||||||||||||||||
Ptentm1Mak/Pten+ | |||||||||||||||||||||||||||||||||
Ptentm2.1Gle/Pten+ | |||||||||||||||||||||||||||||||||
Ptentm1.1Mwst/Ptentm1.1Mwst Tg(S100a4-cre)1Gle/0 (conditional) |
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Ptentm1Hwu/Ptentm1Hwu Tg(KRT14-cre)#Smr/0 (conditional) |
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Ptentm1Hwu/Ptentm1Hwu Tg(MMTV-cre)4Mam/0 (conditional) |
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Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ Ptentm1Hwu/Ptentm1Hwu (conditional) |
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Ptentm1Hwu/Ptentm1Hwu Tg(MMTV-cre)#Tfln/0 (conditional) |
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Ptentm1Hwu/Ptentm1Hwu Tg(Pgc-cre,-secNluc)#Hcz/0 (conditional) |
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Ptentm2Mak/Ptentm2Mak Tg(KRT5-cre)1Xya/0 (conditional) |
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Ptentm2Mak/Ptentm2Mak Tg(Vil1-cre/ERT2)23Syr/0 (conditional) |
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Ptentm2Mak/Ptentm2Mak Tg(MMTV-cre)#Tfln/0 (conditional) |
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Ptentm2Mak/Ptentm2Mak Tg(Wap-cre)11738Mam/0 (conditional) |
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Ptentm1Hwu/Pten+ Tg(KRT14-cre)#Smr/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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