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Symbol
Name
ID
Bmpr2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
MGI:1095407
Phenotype annotations related to cardiovascular system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Abnormal cardiovascular system physiology
Elevated right atrial pressure
Right ventricular failure
Heart murmur
Tricuspid regurgitation
Hypertension
Elevated pulmonary artery pressure
Pulmonary arterial hypertension
Increased pulmonary vascular resistance
Elevated jugular venous pressure
Arrhythmia
Palpitations
Angina pectoris
Syncope
Right ventricular dilatation
Right ventricular hypertrophy
Pulmonary arterial medial hypertrophy
Pulmonary aterial intimal fibrosis
Pulmonary venous occlusion
Arterial intimal fibrosis
Pulmonary artery vasoconstriction
Telangiectasia
Disease(s) Associated with BMPR2
primary pulmonary hypertension
pulmonary venoocclusive disease

Mouse Phenotypes
cardiovascular system phenotype
abnormal pulmonary artery morphology
interrupted aortic arch
artery occlusion
abnormal lung vasculature morphology
absent vitelline blood vessels
abnormal myocardium compact layer morphology
heart right ventricle hypertrophy
persistent truncus arteriosus type i
persistent truncus arteriosus type iv
atrioventricular septal defect
abnormal interventricular septum morphology
muscular ventricular septal defect
abnormal semilunar valve morphology
absent heart valves
increased pulmonary vascular resistance
increased vascular permeability
abnormal vascular smooth muscle physiology
increased vasoconstriction
increased right ventricle systolic pressure
increased pulmonary artery pressure
pulmonary hypertension
Availability Mouse Genotype
Bmpr2b2b2556Clo/Bmpr2b2b2556Clo
Bmpr2tm1Kml/Bmpr2tm1Kml
Bmpr2tm1.1Pley/Bmpr2+ *
Bmpr2tm1Kmi/Bmpr2+
Bmpr2tm1Mmue/Bmpr2+
Tg(Tagln-rtTA)E1Jwst/0
Tg(tetO-Bmpr2*R899X)#Jwst/0
Bmpr2tm1.1Enl/Bmpr2tm1.1Enl
Tg(Acvrl1-cre)L1Spo/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/09/2019
MGI 6.13
The Jackson Laboratory