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Symbol
Name
ID
Brca2
breast cancer 2, early onset
MGI:109337
Phenotype annotations related to integument
Darker colors indicate more annotations
Human Phenotypes
Breast carcinoma
Jaundice
Abnormality of skin pigmentation
Irregular hyperpigmentation
Cafe-au-lait spot
Multiple cafe-au-lait spots
Hypopigmented skin patches
Disease(s) Associated with BRCA2
breast cancer
Fanconi anemia
Fanconi anemia complementation group D1
ovarian cancer
pancreatic cancer

Mouse Phenotypes
abnormal branching of the mammary ductal tree
decreased mammary duct terminal end bud number
increased mammary gland tumor incidence
increased mammary adenocarcinoma incidence
abnormal skin morphology
abnormal epidermal layer morphology
abnormal epidermis stratum basale morphology
absent epidermis stratum corneum
abnormal epidermis stratum spinosum morphology
Availability Mouse Genotype
Brca2tm1Cbl/Brca2tm1Cbl
Brca2tm1Kamc/Brca2tm1Kamc
Brca2tm1Mbn/Brca2+
Brca2tm2.1Sks/Brca2tm1Brd
Brca2tm2Arge/Brca2tm2Arge
Waptm1(cre)Arge/Waptm1(cre)Arge  (conditional)
Brca2tm1Arge/Brca2tm2Arge
Waptm1(cre)Arge/Wap+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory