|
Symbol Name ID |
Irs2
insulin receptor substrate 2 MGI:109334 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Type II diabetes mellitus |
Insulin resistance |
| Disease(s) Associated with IRS2 | ||
| type 2 diabetes mellitus |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
abnormal vascular wound healing |
increased insulin secretion |
abnormal circulating glucose level |
increased fasting circulating glucose level |
increased circulating glucose level |
hyperglycemia |
abnormal circulating hormone level |
decreased circulating testosterone level |
decreased circulating estradiol level |
decreased circulating luteinizing hormone level |
decreased circulating prolactin level |
abnormal circulating insulin level |
increased circulating insulin level |
increased circulating leptin level |
decreased circulating progesterone level |
increased circulating HDL cholesterol level |
increased circulating cholesterol level |
increased circulating free fatty acids level |
increased circulating triglyceride level |
abnormal energy homeostasis |
decreased oxygen consumption |
abnormal glucose homeostasis |
impaired glucose tolerance |
improved glucose tolerance |
decreased skeletal muscle glycogen level |
insulin resistance |
abnormal prolactin level |
abnormal lipid homeostasis |
decreased basal metabolism |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||
| Irs2M1Btlr/Irs2M1Btlr | |||||||||||||||||||||||||||||||
| Irs2tm1Mfw/Irs2tm1Mfw Tg(Ins2-Irs2)13Mfw/0 |
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| Irs2tm1Mfw/Irs2tm1Mfw | |||||||||||||||||||||||||||||||
| Irs2tm1Tka/Irs2tm1Tka | |||||||||||||||||||||||||||||||
| Tg(Ins2-Irs2)13Mfw/0 | |||||||||||||||||||||||||||||||
| Irs2tm1With/Irs2tm1With Tg(Ins2-cre)25Mgn/0 (conditional) |
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| Irs2tm1With/Irs2tm1With Tg(Nes-cre)1Kln/0 (conditional) |
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| Irs2tm1With/Irs2tm1With Tg(Nes-cre)1Kln/? (conditional) |
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| Irs2tm2Mfw/Irs2tm2Mfw Tg(Ins2-cre)25Mgn/0 (conditional) |
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| Irs2tm2Mfw/Irs2tm2Mfw Tg(Ins2-cre)25Mgn/0 Tg(Ins2-Irs2)13Mfw/0 (conditional) |
* | ||||||||||||||||||||||||||||||
| Irs2tm2Mfw/Irs2tm2Mfw Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
* | ||||||||||||||||||||||||||||||
| Irs2tm2Mfw/Irs2tm2Mfw Tg(Nes-cre)1Kln/? (conditional) |
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| Irs2tm2Tka/Irs2tm2Tka Tg(Ins2-cre)25Mgn/0 (conditional) |
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| Irs2tm2Tka/Irs2tm2Tka Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
* | ||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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