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Symbol
Name
ID
Smo
smoothened, frizzled class receptor
MGI:108075
Phenotype annotations related to skeleton
Darker colors indicate more annotations
Human Phenotypes
Back pain
Disease(s) Associated with SMO
pancreatic cancer

Mouse Phenotypes
decreased chondrocyte proliferation
abnormal cranium morphology
abnormal basisphenoid bone morphology
absent styloid process
Meckel's cartilage hypoplasia
short Meckel's cartilage
abnormal sphenoid bone morphology
small alisphenoid bone
absent orbitosphenoid bone
absent presphenoid bone
absent pterygoid process
abnormal temporal bone morphology
small temporal bone squamous part
abnormal ethmoid bone morphology
abnormal tooth morphology
abnormal incisor morphology
absent lower incisors
abnormal molar morphology
abnormal molar cusp morphology
fused molars
abnormal ameloblast morphology
absent Tomes' process
abnormal enamel organ morphology
abnormal stellate reticulum morphology
abnormal inner dental epithelium morphology
abnormal outer dental epithelium morphology
absent enamel cord
abnormal mandible morphology
abnormal mandibular condyloid process morphology
abnormal maxilla morphology
absent lacrimal bone
nasal bone hypoplasia
absent palatine bone
absent vomer bone
small zygomatic bone
absent incus
absent gonial bone
absent malleus
absent stapes
absent middle ear ossicles
absent Reichert cartilage
short humerus
short ulna
short fibula
short tibia
abnormal thyroid cartilage morphology
decreased length of long bones
short scapula
abnormal skeleton development
Availability Mouse Genotype
Smotm1Amc/Smotm2Amc
H2az2Tg(Wnt1-cre)11Rth/H2az2+  (conditional)
Smotm1Amc/Smotm2Amc
Tg(KRT14-cre)1Amc/0  (conditional)
Smotm1Amc/Smotm2Amc
Tg(Col2a1-cre)10Amc/0  (conditional)
Smotm1Amc/Smotm2Amc
Tg(Col2a1-cre)15Amc/0  (conditional)
Smotm1Amc/Smotm2Amc
Tg(Col2a1-cre)3Amc/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory