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Symbol
Name
ID
Smo
smoothened, frizzled class receptor
MGI:108075
Phenotype annotations related to craniofacial
Darker colors indicate more annotations

Mouse Phenotypes
abnormal sixth pharyngeal arch artery morphology
abnormal cranium morphology
abnormal basisphenoid bone morphology
absent styloid process
Meckel's cartilage hypoplasia
short Meckel's cartilage
abnormal sphenoid bone morphology
small alisphenoid bone
absent orbitosphenoid bone
absent presphenoid bone
absent pterygoid process
abnormal temporal bone morphology
small temporal bone squamous part
abnormal ethmoid bone morphology
abnormal tooth morphology
abnormal incisor morphology
absent lower incisors
abnormal molar morphology
abnormal molar cusp morphology
fused molars
abnormal ameloblast morphology
absent Tomes' process
abnormal enamel organ morphology
abnormal stellate reticulum morphology
abnormal inner dental epithelium morphology
abnormal outer dental epithelium morphology
absent enamel cord
abnormal mandible morphology
abnormal mandibular condyloid process morphology
abnormal maxilla morphology
absent lacrimal bone
nasal bone hypoplasia
absent palatine bone
absent vomer bone
small zygomatic bone
absent incus
absent gonial bone
absent malleus
absent stapes
absent middle ear ossicles
abnormal craniofacial development
absent Reichert cartilage
abnormal frontonasal prominence morphology
abnormal first pharyngeal arch morphology
fused first pharyngeal arch
abnormal face development
absent tongue
nasal septum hypoplasia
abnormal head shape
Availability Mouse Genotype
Smotm1.1Pab/Smotm1.1Pab
Tg(Neurod2-Smo*A1)199Jols/Tg(Neurod2-Smo*A1)199Jols
Tg(Neurod2-Smo*A2)#Jols/0
Gt(ROSA)26Sortm7(SMO*/YFP)Amc/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+  (conditional)
Smotm1Amc/Smotm2Amc
H2az2Tg(Wnt1-cre)11Rth/H2az2+  (conditional)
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/?
H2az2Tg(Wnt1-cre)11Rth/H2az2+  (conditional)
Smotm1Amc/Smotm2Amc
Isl1tm1(cre)Sev/Isl1+  (conditional)
Smotm1Amc/Smotm2Amc
Tg(KRT14-cre)1Amc/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory