Symbol Name ID |
Sptlc2
serine palmitoyltransferase, long chain base subunit 2 MGI:108074 |
Darker colors indicate more annotations |
Human Phenotypes | Anhidrosis |
Skin ulcer |
Disease(s) Associated with SPTLC2 | ||
hereditary sensory and autonomic neuropathy type 1C |
Mouse Phenotypes | sebaceous gland atrophy |
abnormal dendritic epidermal T cell morphology |
impaired skin barrier function |
skin inflammation |
alopecia |
sparse hair |
abnormal epidermis stratum corneum morphology |
hyperkeratosis |
abnormal epidermis stratum granulosum morphology |
abnormal epidermal lamellar body morphology |
absent epidermis stratum granulosum |
acanthosis |
epidermal hyperplasia |
dry skin |
reddish skin |
scaly skin |
skin lesions |
psoriasis |
delayed skin barrier formation |
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Availability | Mouse Genotype | |||||||||||||||||||
Sptlc2tm1Yhir/Sptlc2tm1Yhir Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ (conditional) |
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Sptlc2tm1Yhir/Sptlc2tm1Yhir Tg(KRT5-cre)1Tak/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/19/2024 MGI 6.23 |
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