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Symbol
Name
ID
Traf3
TNF receptor-associated factor 3
MGI:108041
Phenotype annotations related to immune system
Darker colors indicate more annotations

Mouse Phenotypes
decreased B cell apoptosis
decreased thymocyte number
abnormal B cell differentiation
increased transitional stage B cell number
decreased double-positive T cell number
decreased mature B cell number
increased follicular B cell number
increased marginal zone B cell number
increased B cell number
decreased CD4-positive, alpha beta T cell number
decreased CD8-positive, alpha-beta T cell number
decreased T cell number
decreased leukocyte cell number
abnormal leukocyte morphology
enlarged spleen
spleen hypoplasia
abnormal spleen germinal center morphology
increased spleen white pulp amount
abnormal B cell physiology
increased IgA level
increased IgG2a level
increased IgG2b level
increased IgG3 level
decreased IgG level
increased IgG level
increased IgM level
abnormal T cell physiology
abnormal immune system organ morphology
abnormal lymph node B cell domain morphology
enlarged lymph nodes
lymph node hyperplasia
abnormal immune system physiology
abnormal adaptive immunity
impaired humoral immune response
autoimmune response
increased anti-double stranded DNA antibody level
decreased response to antigen
Availability Mouse Genotype
Traf3m1Btlr/Traf3m1Btlr
Traf3m2Btlr/Traf3m2Btlr
Traf3tm1Bal/Traf3tm1Bal
Traf3tm1Bshp/Traf3tm1Bshp
Cd19tm1(cre)Cgn/Cd19+  (conditional)
Cd19tm1(cre)Cgn/Cd19+
Traf3tm1Rbr/Traf3tm1Rbr  (conditional)
Tg(Lck-cre)I57Jxm/?
Traf3tm1Rbr/Traf3tm1Rbr  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory