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chemokine (C-C motif) receptor 4
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
immune system phenotype
decreased eosinophil cell number
increased neutrophil cell number
increased CD8-positive, alpha-beta T cell number
increased NK T cell number
decreased lymphocyte cell number
decreased macrophage cell number
increased macrophage cell number
decreased IgE level
increased IgE level
increased IgG1 level
abnormal splenocyte physiology
abnormal cytokine secretion
abnormal chemokine secretion
increased interferon-gamma secretion
decreased interleukin-1 beta secretion
decreased interleukin-10 secretion
increased interleukin-10 secretion
decreased interleukin-13 secretion
decreased interleukin-4 secretion
increased interleukin-4 secretion
decreased interleukin-5 secretion
increased interleukin-5 secretion
decreased tumor necrosis factor secretion
increased tumor necrosis factor secretion
decreased susceptibility to endotoxin shock
decreased susceptibility to fungal infection
increased length of allograft survival
Availability Mouse Genotype
Ccr4tm1Pwr/Ccr4tm1Pwr *

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory