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Symbol
Name
ID
Myh9
myosin, heavy polypeptide 9, non-muscle
MGI:107717
Phenotype annotations related to hematopoietic system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Abnormal bleeding
Epistaxis
Spontaneous, recurrent epistaxis
Menorrhagia
Prolonged bleeding time
Bruising susceptibility
Neutrophil inclusion bodies
Leukocyte inclusion bodies
Thrombocytopenia
Congenital thrombocytopenia
Increased mean platelet volume
Giant platelets
Abnormal thrombosis
Disease(s) Associated with MYH9
MYH-9 related disease

Mouse Phenotypes
hematopoietic system phenotype
abnormal megakaryocyte differentiation
abnormal leukocyte migration
abnormal leukocyte adhesion
abnormal thrombopoiesis
abnormal megakaryocyte morphology
increased megakaryocyte cell number
abnormal neutrophil morphology
abnormal platelet morphology
thrombocytopenia
abnormal platelet shape
decreased CD8-positive, alpha-beta T cell number
abnormal T cell physiology
abnormal CD8-positive, alpha-beta T cell physiology
abnormal platelet physiology
Availability Mouse Genotype
Myh9tm1.1(MYH9*)Mjk/Myh9tm1.1(MYH9*)Mjk
Myh9tm1.2Gac/Myh9tm1.2Gac *
Myh9tm7.1Rsad/Myh9tm7.1Rsad
Myh9Gt(Betageo-btk)1Dash/Myh9+ *
Myh9tm1.1(MYH9*)Mjk/Myh9+
Myh9tm1.1Dash/Myh9+
Myh9tm6.1(EGFP/MYH9*)Rsad/Myh9+
Myh9tm7.1Rsad/Myh9+
Myh9tm1.1Gac/Myh9tm1.1Gac
Tg(Pf4-icre)Q3Rsko/0  (conditional)
Myh9tm5Rsad/Myh9tm5Rsad  (conditional)
Myh9tm5Rsad/Myh9tm5Rsad
Tg(Lck-cre)#Nik/0  (conditional)
Myh9tm1.1Gac/Myh9+
Tg(Pf4-icre)Q3Rsko/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory