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Symbol
Name
ID
Ifnar1
interferon (alpha and beta) receptor 1
MGI:107658
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
immune system phenotype
decreased NK cell number
decreased monocyte cell number
increased leukocyte cell number
abnormal osteoclast morphology
abnormal immunoglobulin level
decreased IgG1 level
decreased IgG2a level
decreased IgG3 level
decreased IgM level
abnormal NK cell physiology
impaired natural killer cell mediated cytotoxicity
abnormal CD8-positive, alpha-beta T cell physiology
abnormal macrophage physiology
increased circulating interleukin-12 level
abnormal dendritic cell physiology
abnormal cytokine secretion
decreased interferon-alpha secretion
decreased interferon-beta secretion
abnormal interferon-gamma secretion
decreased interleukin-6 secretion
decreased tumor necrosis factor secretion
abnormal inflammatory response
abnormal response to infection
altered susceptibility to infection
increased susceptibility to bacterial infection induced morbidity/mortality
increased susceptibility to viral infection induced morbidity/mortality
increased susceptibility to viral infection
Availability Mouse Genotype
Ifnar1m1Btlr/Ifnar1m1Btlr *
Ifnar1m2Btlr/Ifnar1m2Btlr
Ifnar1tm1Agt/Ifnar1tm1Agt *
Ifnar1tm1Pjh/Ifnar1tm1Pjh
Ifnar1tm2a(EUCOMM)Wtsi/Ifnar1tm2a(EUCOMM)Wtsi
Cd19tm1(cre)Cgn/Cd19+
Ifnar1tm1Uka/Ifnar1tm1Uka  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory