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Symbol
Name
ID
Ifng
interferon gamma
MGI:107656
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Leukocytosis
Pulmonary lymphangiomyomatosis
Hepatosplenomegaly
Splenomegaly
Skin rash
BCGosis
Disease(s) Associated with IFNG
immunodeficiency 69
tuberous sclerosis 2

Mouse Phenotypes
immune system phenotype
myocarditis
abnormal dendritic cell chemotaxis
abnormal macrophage chemotaxis
abnormal diapedesis
increased splenocyte proliferation
peritoneal inflammation
stomach inflammation
abnormal uterine NK cell morphology
increased uterine NK cell number
thymus atrophy
pancreas inflammation
enlarged spleen
abnormal B cell differentiation
increased neutrophil cell number
increased granulocyte number
decreased mature B cell number
decreased pre-B cell number
increased CD8-positive, alpha-beta T cell number
increased NK T cell number
increased T cell number
increased lymphocyte cell number
increased macrophage cell number
increased monocyte cell number
decreased leukocyte cell number
increased leukocyte cell number
abnormal spleen morphology
abnormal spleen red pulp morphology
spleen atrophy
abnormal spleen white pulp morphology
pale spleen
abnormal B cell physiology
abnormal immunoglobulin level
decreased IgA level
decreased IgE level
increased IgE level
increased IgG1 level
decreased IgG2a level
decreased IgG2b level
decreased IgG3 level
decreased IgG level
decreased IgM level
decreased immunoglobulin level
abnormal NK cell physiology
impaired natural killer cell mediated cytotoxicity
abnormal uterine NK cell physiology
abnormal cytotoxic T cell physiology
abnormal T cell activation
abnormal macrophage physiology
abnormal MHC II cell surface expression on macrophages
abnormal circulating cytokine level
abnormal circulating interferon level
increased circulating interleukin-12 level
increased circulating interleukin-6 level
abnormal cytokine level
abnormal lymph node morphology
enlarged mesenteric lymph nodes
abnormal lymph node cell ratio
abnormal adaptive immunity
abnormal dendritic cell physiology
abnormal Langerhans cell physiology
abnormal dendritic cell antigen presentation
abnormal type IV hypersensitivity reaction
decreased susceptibility to type IV hypersensitivity reaction
increased susceptibility to type IV hypersensitivity reaction
abnormal humoral immune response
abnormal cytokine secretion
abnormal interferon-gamma secretion
decreased interferon-gamma secretion
decreased interleukin-10 secretion
increased interleukin-10 secretion
increased interleukin-12 secretion
increased interleukin-17 secretion
increased interleukin-2 secretion
increased interleukin-4 secretion
increased interleukin-5 secretion
abnormal immune tolerance
abnormal susceptibility to autoimmune disorder
decreased susceptibility to autoimmune disorder
decreased susceptibility to autoimmune diabetes
increased susceptibility to experimental autoimmune encephalomyelitis
decreased autoantibody level
decreased anti-nuclear antigen antibody level
decreased anti-double stranded DNA antibody level
abnormal inflammatory response
decreased inflammatory response
CNS inflammation
liver inflammation
glomerulonephritis
abnormal response to infection
abnormal susceptibility to infection
increased susceptibility to bacterial infection
increased susceptibility to bacterial infection induced morbidity/mortality
decreased susceptibility to parasitic infection induced morbidity/mortality
increased susceptibility to parasitic infection induced morbidity/mortality
increased susceptibility to Herpesvirales infection induced morbidity/mortality
increased susceptibility to Coronaviridae infection induced morbidity/mortality
decreased susceptibility to parasitic infection
increased susceptibility to parasitic infection
increased susceptibility to Herpesvirales infection
increased susceptibility to Coronaviridae infection
abnormal response to transplant
decreased length of allograft survival
Availability Mouse Genotype
Ifngtm1.1Hayg/Ifngtm1.1Hayg
Ifngtm1Lky/Ifngtm1Lky *
Ifngtm1Ts/Ifngtm1Ts *! ! ! !
Ifngtm1Yiw/Ifngtm1Yiw ! !
Tg(APCS-Ifng)5Imeg/0
Tg(GFAP-tTA)78Pop/0
Tg(tetO-Ifng)184Pop/0
Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli/0

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory