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Symbol
Name
ID
Kcnj11
potassium inwardly rectifying channel, subfamily J, member 11
MGI:107501
Phenotype annotations related to homeostasis/metabolism
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Ketoacidosis
Hyperglycemia
Hypoglycemia
Hypoglycemic seizures
Glycosuria
Diabetes mellitus
Transient neonatal diabetes mellitus
Maternal diabetes
Maturity-onset diabetes of the young
Type II diabetes mellitus
Fasting hyperinsulinemia
Hyperinsulinemic hypoglycemia
Insulin resistance
Dehydration
Asymptomatic hyperammonemia
Ketonuria
Disease(s) Associated with KCNJ11
hyperinsulinemic hypoglycemia
maturity-onset diabetes of the young type 13
permanent neonatal diabetes mellitus
transient neonatal diabetes mellitus
type 2 diabetes mellitus

Mouse Phenotypes
homeostasis/metabolism phenotype
decreased aerobic running capacity
decreased glucagon secretion
decreased insulin secretion
increased insulin secretion
decreased susceptibility to diet-induced obesity
abnormal circulating glucose level
decreased fasted circulating glucose level
hypoglycemia
increased circulating glucose level
hyperglycemia
increased circulating atrial natriuretic factor
abnormal circulating glucagon level
decreased circulating glucagon level
increased circulating glucagon level
decreased circulating insulin level
increased circulating insulin level
increased energy expenditure
increased oxygen consumption
abnormal glucose homeostasis
impaired glucose tolerance
improved glucose tolerance
increased insulin sensitivity
Availability Mouse Genotype
Kcnj11tm1b(EUCOMM)Wtsi/Kcnj11tm1b(EUCOMM)Wtsi
Kcnj11tm1Sse/Kcnj11tm1Sse
Kcnj11tm1Sse/Kcnj11tm1Sse
Tg(Ins1-Kcnj11*)#Nich/?
*
Kcnj11Y12stop/Kcnj11Y12stop
Kcnj11tm1Sse/Kcnj11+
Tg(Ins1-Kcnj11*)#Nich/?
Tg(Ins1-Kcnj11*)#Nich/?
Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+
Tg(Ins2-cre)23Herr/0  (conditional)
Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+
Tg(Ins2-cre)23Herr/0  (conditional)
Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+
Tg(Pdx1-cre/Esr1*)#Dam/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory