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Symbol
Name
ID
Kcnj11
potassium inwardly rectifying channel, subfamily J, member 11
MGI:107501
Phenotype annotations related to endocrine/exocrine glands
Darker colors indicate more annotations
Human Phenotypes
Diabetes mellitus
Transient neonatal diabetes mellitus
Maternal diabetes
Maturity-onset diabetes of the young
Type II diabetes mellitus
Fasting hyperinsulinemia
Hyperinsulinemic hypoglycemia
Abnormality of the pancreatic islet cells
Beta-cell dysfunction
Pancreatic islet-cell hyperplasia
Disease(s) Associated with KCNJ11
hyperinsulinemic hypoglycemia
maturity-onset diabetes of the young type 13
permanent neonatal diabetes mellitus
transient neonatal diabetes mellitus
type 2 diabetes mellitus

Mouse Phenotypes
abnormal pancreatic islet morphology
abnormal pancreatic alpha cell morphology
decreased pancreatic alpha cell number
increased pancreatic alpha cell number
abnormal pancreatic beta cell morphology
decreased pancreatic beta cell number
decreased pancreatic islet number
small pancreatic islets
abnormal pancreas morphology
decreased pancreas weight
decreased glucagon secretion
abnormal pancreatic beta cell physiology
decreased insulin secretion
increased insulin secretion
Availability Mouse Genotype
Kcnj11tm1Sse/Kcnj11tm1Sse
Kcnj11tm1Sse/Kcnj11tm1Sse
Tg(Ins1-Kcnj11*)#Nich/?
Kcnj11Y12stop/Kcnj11Y12stop
Kcnj11tm1Sse/Kcnj11+
Tg(Ins1-Kcnj11*)#Nich/?
Tg(Ins1-Kcnj11*)#Nich/?
Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+
Tg(Ins2-cre)23Herr/0  (conditional)
Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+
Tg(Ins2-cre)23Herr/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory