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Symbol
Name
ID
Inpp5d
inositol polyphosphate-5-phosphatase D
MGI:107357
Phenotype annotations related to immune system
Darker colors indicate more annotations

Mouse Phenotypes
abnormal granulocyte differentiation
abnormal mononuclear cell differentiation
abnormal monocyte differentiation
abnormal osteoclast differentiation
abnormal macrophage chemotaxis
intestinal inflammation
ileum inflammation
enlarged thymus
small thymus
decreased thymocyte number
abnormal lymphopoiesis
abnormal B cell differentiation
decreased pro-B cell number
abnormal T cell differentiation
abnormal CD8-positive, alpha-beta T cell differentiation
abnormal myelopoiesis
increased neutrophil cell number
increased dendritic cell number
abnormal lymphocyte cell number
absent marginal zone B cells
increased B-1 B cell number
decreased B cell number
decreased pre-B cell number
decreased NK cell number
increased NK cell number
increased effector memory CD4-positive, alpha-beta T cell number
decreased CD4-positive, alpha beta T cell number
increased central memory CD8 positive, alpha-beta T cell number
increased effector memory CD8-positive, alpha-beta T cell number
decreased CD8-positive, naive alpha-beta T cell number
decreased CD8-positive, alpha-beta T cell number
increased CD8-positive, alpha-beta T cell number
decreased alpha-beta T cell number
decreased lymphocyte cell number
increased macrophage cell number
increased osteoclast cell number
increased monocyte cell number
increased leukocyte cell number
abnormal lymphocyte morphology
abnormal NK cell morphology
abnormal osteoclast morphology
abnormal spleen marginal zone macrophage morphology
abnormal myeloid leukocyte morphology
increased spleen weight
enlarged spleen
spleen hyperplasia
abnormal leukocyte physiology
abnormal eosinophil physiology
increased mast cell degranulation
abnormal neutrophil physiology
abnormal B cell physiology
increased IgG2a level
increased IgM level
increased immunoglobulin level
impaired natural killer cell mediated cytotoxicity
abnormal T cell physiology
abnormal CD4-positive, alpha-beta T cell physiology
abnormal CD8-positive, alpha-beta T cell physiology
abnormal cytotoxic T cell physiology
decreased cytotoxic T cell cytolysis
abnormal osteoclast physiology
increased circulating interleukin-6 level
abnormal interferon level
abnormal interleukin level
abnormal lymph node germinal center morphology
enlarged lymph nodes
abnormal cell-mediated immunity
abnormal humoral immune response
increased interferon-beta secretion
abnormal interleukin secretion
increased tumor necrosis factor secretion
lung inflammation
decreased susceptibility to parasitic infection
decreased susceptibility to graft versus host disease
Availability Mouse Genotype
Inpp5del20/Inpp5del20
Inpp5dm1Anu/Inpp5dm1Anu
Inpp5dm1Btlr/Inpp5dm1Btlr
Inpp5dm2Btlr/Inpp5dm2Btlr
Inpp5dm4Btlr/Inpp5dm4Btlr
Inpp5dm5Btlr/Inpp5dm5Btlr
Inpp5dtm1.1Wgk/Inpp5dtm1.1Wgk
Inpp5dtm1Dmt/Inpp5dtm1Dmt
Inpp5dtm1Rkh/Inpp5dtm1Rkh
Inpp5dM3Btlr/Inpp5d+
Inpp5dtm1Rav/Inpp5dtm1Rav
Tg(Cd4-cre)1Cwi/?  (conditional)
Inpp5dtm1Wgk/Inpp5dtm1Wgk
Tg(Mx1-cre)1Cgn/0  (conditional)
Inpp5dtm1Rav/Inpp5dtm1.1Rav
Lyz2tm1(cre)Ifo/Lyz2+  (conditional)
Inpp5dtm1Wgk/Inpp5dtm1.1Wgk
Tg(Mx1-cre)1Cgn/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory