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Symbol
Name
ID
Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
MGI:105368
Phenotype annotations related to hearing/vestibular/ear
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Prelingual sensorineural hearing impairment
Disease(s) Associated with ATP2B2
autosomal recessive nonsyndromic deafness 12

Mouse Phenotypes
hearing/vestibular/ear phenotype
abnormal inner ear morphology
decreased cochlear hair cell number
absent cochlear hair cells
abnormal cochlear hair cell stereociliary bundle morphology
abnormal outer hair cell stereociliary bundle morphology
absent outer hair cell stereocilia
cochlear inner hair cell degeneration
cochlear outer hair cell degeneration
cochlear hair cell degeneration
abnormal organ of Corti morphology
decreased organ of Corti supporting cell number
absent organ of Corti supporting cells
absent pillar cells
pillar cell degeneration
absent tunnel of Corti
organ of Corti degeneration
cochlear degeneration
absent vestibular hair cells
abnormal inner ear vestibule morphology
abnormal vestibular saccule morphology
vestibular saccular degeneration
absent otoliths
abnormal cochlear hair cell physiology
abnormal cochlear microphonics
abnormal hair cell mechanoelectric transduction
abnormal vestibular hair cell physiology
abnormal hearing physiology
abnormal auditory brainstem response
abnormal auditory brainstem response waveform shape
decreased threshold for auditory brainstem response
increased or absent threshold for auditory brainstem response
abnormal cochlear nerve compound action potential
abnormal distortion product otoacoustic emission
absent distortion product otoacoustic emissions
increased susceptibility to age-related hearing loss
increased susceptibility to noise-induced hearing loss
impaired hearing
deafness
sensorineural hearing loss
syndromic hearing loss
abnormal vestibular system physiology
absent linear vestibular evoked potential
reduced linear vestibular evoked potential
Availability Mouse Genotype
Atp2b2Deaf11/Atp2b2Deaf11
Atp2b2Deaf13/Atp2b2Deaf13
Atp2b2dfw-2J/Atp2b2dfw-2J
Atp2b2dfw-3J/Atp2b2dfw-3J
Atp2b2dfw-i5/Atp2b2dfw-i5 !
Atp2b2dfw/Atp2b2dfw
Atp2b2Elfin/Atp2b2Elfin
Atp2b2Obv/Atp2b2Obv
Atp2b2tm1Ges/Atp2b2tm1Ges
Atp2b2Tmy/Atp2b2Tmy
Atp2b2wri/Atp2b2wri
Atp2b2Deaf11/Atp2b2+
Atp2b2Deaf11/Atp2b2Deaf13
Atp2b2Deaf13/Atp2b2+
Atp2b2dfw-2J/Atp2b2+ *
Atp2b2dfw-i5/Atp2b2+
Atp2b2dfw/Atp2b2+
Atp2b2Elfin/Atp2b2+
Atp2b2Obv/Atp2b2+
Atp2b2tm1Ges/Atp2b2+ ! !
Atp2b2Tmy/Atp2b2+ *
Atp2b2wri/Atp2b2+

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory