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Symbol
Name
ID
Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
MGI:105089
Phenotype annotations related to reproductive system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Hypergonadotropic hypogonadism
Primary amenorrhea
Premature ovarian insufficiency
Abnormality of the uterus
Hypoplasia of the uterus
Gonadal dysgenesis
Disease(s) Associated with HSD17B4
Perrault syndrome

Mouse Phenotypes
reproductive system phenotype
abnormal male germ cell morphology
abnormal spermatid morphology
abnormal testis morphology
abnormal seminiferous tubule morphology
seminiferous tubule degeneration
small testis
small uterus
abnormal gametogenesis
abnormal spermatogenesis
abnormal male reproductive system morphology
abnormal epididymis morphology
reduced female fertility
decreased litter size
male infertility
reduced male fertility
Availability Mouse Genotype
Hsd17b4em1(IMPC)Tcp/Hsd17b4em1(IMPC)Tcp
Hsd17b4tm1Baes/Hsd17b4tm1Baes
Hsd17b4tm2Baes/Hsd17b4tm2Baes
Cnptm1(cre)Kan/Cnp+  (conditional)
*
Hsd17b4tm2Baes/Hsd17b4tm2Baes
Tg(Nes-cre)1Kln/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory