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Symbol
Name
ID
Was
Wiskott-Aldrich syndrome
MGI:105059
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Increased circulating IgA level
Decreased circulating total IgM
Abnormal delayed hypersensitivity skin test
Lymphopenia
Absent microvilli on the surface of peripheral blood lymphocytes
Sinusitis
Recurrent upper respiratory tract infections
Inflammation of the large intestine
Otitis media
Eczema
Pneumonia
Reduced lymphocyte surface expression of CD43
Recurrent lower respiratory tract infections
Meningitis
Disease(s) Associated with WAS
thrombocytopenia
Wiskott-Aldrich syndrome

Mouse Phenotypes
immune system phenotype
abnormal osteoclast differentiation
abnormal B cell proliferation
decreased T cell proliferation
colitis
thymus hypoplasia
abnormal thymocyte activation
abnormal double-negative T cell morphology
abnormal double-positive T cell morphology
decreased double-positive T cell number
increased neutrophil cell number
abnormal mast cell morphology
abnormal B cell number
increased germinal center B cell number
decreased mature B cell number
decreased follicular B cell number
decreased marginal zone B cell number
increased follicular B cell number
increased plasma cell number
decreased B cell number
increased B cell number
decreased NK cell number
decreased T cell number
decreased lymphocyte cell number
increased monocyte cell number
increased leukocyte cell number
abnormal dendritic cell morphology
abnormal lymphocyte morphology
spleen hyperplasia
increased splenocyte number
abnormal mast cell physiology
abnormal B cell physiology
increased IgA level
increased IgE level
increased IgM level
abnormal osteoclast physiology
lymphoid hypoplasia
abnormal dendritic cell physiology
abnormal dendritic cell antigen presentation
abnormal cytokine secretion
increased autoantibody level
increased anti-chromatin antibody level
increased anti-double stranded DNA antibody level
increased anti-single stranded DNA antibody level
glomerulonephritis
Availability Mouse Genotype
Wastm1Itl/Wastm1Itl
Wastm1Kas/Wastm1Kas
Wastm1Sbs/Wastm1Sbs *
Wastm2Itl/Wastm2Itl
Wastm1Itl/Y
Wastm1Sbs/Y
Wastm2Itl/Y
Cd79atm1(cre)Reth/Cd79a+
Wastm1.1Ldn/Wastm1.1Ldn  (conditional)
Cd79atm1(cre)Reth/Cd79a+
Wastm1.1Ldn/Y  (conditional)
Cd79atm1(cre)Reth/Cd79a+
Wastm1.1Ldn/Was+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory