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Symbol
Name
ID
Was
Wiskott-Aldrich syndrome
MGI:105059
Phenotype annotations related to hematopoietic system
Darker colors indicate more annotations
Human Phenotypes
Abnormal bleeding
Epistaxis
Gingival bleeding
Hematemesis
Melena
Joint hemorrhage
Persistent bleeding after trauma
Prolonged bleeding time
Bruising susceptibility
Purpura
Petechiae
Hemolytic anemia
Anemia of inadequate production
Iron deficiency anemia
Poikilocytosis
Acanthocytosis
Lymphopenia
Absent microvilli on the surface of peripheral blood lymphocytes
Thrombocytopenia
Congenital thrombocytopenia
Intermittent thrombocytopenia
Decreased mean platelet volume
Disease(s) Associated with WAS
thrombocytopenia
Wiskott-Aldrich syndrome

Mouse Phenotypes
abnormal osteoclast differentiation
abnormal B cell proliferation
decreased T cell proliferation
thymus hypoplasia
abnormal thymocyte activation
abnormal double-negative T cell morphology
abnormal double-positive T cell morphology
decreased double-positive T cell number
abnormal bone marrow cell morphology/development
abnormal megakaryocyte morphology
increased neutrophil cell number
abnormal mast cell morphology
thrombocytopenia
abnormal B cell number
increased germinal center B cell number
decreased mature B cell number
decreased follicular B cell number
decreased marginal zone B cell number
increased follicular B cell number
increased plasma cell number
decreased B cell number
increased B cell number
decreased NK cell number
decreased T cell number
decreased lymphocyte cell number
increased monocyte cell number
increased leukocyte cell number
abnormal dendritic cell morphology
abnormal lymphocyte morphology
spleen hyperplasia
increased splenocyte number
abnormal mast cell physiology
abnormal B cell physiology
increased IgA level
increased IgE level
increased IgM level
abnormal osteoclast physiology
Availability Mouse Genotype
Wastm1Itl/Wastm1Itl
Wastm1Kas/Wastm1Kas
Wastm1Sbs/Wastm1Sbs
Wastm2Itl/Wastm2Itl
Wastm1Itl/Y
Wastm1Sbs/Y
Wastm2Itl/Y
Cd79atm1(cre)Reth/Cd79a+
Wastm1.1Ldn/Wastm1.1Ldn  (conditional)
Cd79atm1(cre)Reth/Cd79a+
Wastm1.1Ldn/Y  (conditional)
Cd79atm1(cre)Reth/Cd79a+
Wastm1.1Ldn/Was+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory