Symbol Name ID |
Prkar1a
protein kinase, cAMP dependent regulatory, type I, alpha MGI:104878 |
Darker colors indicate more annotations |
Human Phenotypes | Hyperphosphatemia |
Diabetes mellitus |
Elevated circulating calcitonin concentration |
Elevated circulating parathyroid hormone level |
Decreased circulating ACTH concentration |
Decreased circulating dehydroepiandrosterone concentration |
Increased serum testosterone level |
Elevated circulating growth hormone concentration |
Increased circulating insulin-like growth factor 1 concentration |
Elevated circulating thyroid-stimulating hormone concentration |
Increased circulating cortisol level |
Primary hypercortisolism |
Paradoxical increased cortisol secretion on dexamethasone suppression test |
Increased urinary cortisol level |
Epiphyseal stippling |
Neonatal epiphyseal stippling |
Disease(s) Associated with PRKAR1A | ||||||||||||||||
acrodysostosis | ||||||||||||||||
Carney complex | ||||||||||||||||
primary pigmented nodular adrenocortical disease |
Mouse Phenotypes | increased circulating corticosterone level |
increased circulating parathyroid hormone level |
increased circulating growth hormone level |
decreased thyroid-stimulating hormone level |
increased thyroxine level |
abnormal urine homeostasis |
decreased physiological sensitivity to xenobiotic |
enhanced wound healing |
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Availability | Mouse Genotype | ||||||||
Prkar1atm1Gsm/Prkar1atm1Gsm | |||||||||
Prkar1atm1.1Geno/Prkar1a+ | |||||||||
Prkar1atm1.2Lsk/Prkar1atm1.2Lsk Tg(Ghrhr-cre)3242Lsk/0 (conditional) |
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Prkar1atm1.2Lsk/Prkar1atm1.2Lsk Tg(TPO-cre)1Shk/0 (conditional) |
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Prkar1atm1Lsk/Prkar1atm1Lsk Tg(Akr1b7-cre)1Anm/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/19/2024 MGI 6.23 |
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