Symbol
Name
ID

Akt2
thymoma viral proto-oncogene 2
MGI:104874

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes

Increased circulating free fatty acid level

Hypoglycemia

Fasting hypoglycemia

Hypoglycemic seizures

Hypoketotic hypoglycemia

Neonatal hypoglycemia

Nonketotic hypoglycemia

Type II diabetes mellitus

Insulin resistance

Increased hepatic glycogen content

Abnormal circulating insulin concentration

Hypoinsulinemia

Disease(s) Associated with AKT2

hypoinsulinemic hypoglycemia with hemihypertrophy

type 2 diabetes mellitus

Mouse Phenotypes

decreased susceptibility to diet-induced obesity

decreased circulating glucose level

hyperglycemia

increased circulating testosterone level

decreased circulating insulin level

increased circulating insulin level

decreased circulating leptin level

abnormal glucose homeostasis

impaired glucose tolerance

insulin resistance

decreased liver triglyceride level

Availability

Mouse Genotype

Akt2^tm1.1Mbb/Akt2^tm1.1Mbb

Akt2^tm1Hem/Akt2^tm1Hem

Akt2^tm1Rsg/Akt2^tm1Rsg

Akt2^tm1.2Mbb/Akt2^tm1.2Mbb
Tg(Alb1-cre)1Khk/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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