About Help FAQ

Symbol
Name
ID

Tnf
tumor necrosis factor
MGI:104798

Phenotype annotations related to mortality/aging

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Death in infancy	Miscarriage	Sudden cardiac death
Disease(s) Associated with TNF	Death in infancy	Miscarriage	Sudden cardiac death
coronary artery disease
Gaucher's disease
systemic lupus erythematosus

Mouse Phenotypes		mortality/aging	increased susceptibility to bacterial infection induced morbidity/mortality	decreased susceptibility to induced morbidity/mortality	increased susceptibility to induced morbidity/mortality	premature death	lethality throughout fetal growth and development, complete penetrance	prenatal lethality, complete penetrance
Availability	Mouse Genotype	mortality/aging		decreased susceptibility to induced morbidity/mortality	increased susceptibility to induced morbidity/mortality	premature death		prenatal lethality, complete penetrance
	Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug
	Tnf^Bpsm1/Tnf^Bpsm1	*!
	Tnf^em4Boui/Tnf^em4Boui
	Tnf^em5Boui/Tnf^em5Boui
	Tnf^R8H/Tnf^R8H
	Tnf^tm2Gkl/Tnf^tm2Gkl
	Tnf^Bpsm1/Tnf⁺	*!				!
	Tnf^em4Boui/Tnf⁺
	Tg(SFTPC-Tnf)2Pva/0
	Tg(Myh6-Tnf)1Brgi/?
	Tg(Myh6-Tnf)2Brgi/?
	Tnf^tm1.1Sned/Tnf^tm1.1Sned Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)
	Tnf^tm1.1Sned/Tnf^tm1.1Sned Tg(Cd4-cre)1Cwi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23