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Symbol
Name
ID
Tnf
tumor necrosis factor
MGI:104798
Phenotype annotations related to growth/size/body
Darker colors indicate more annotations
Human Phenotypes
Splenomegaly
Hepatosplenomegaly
Abnormal abdomen morphology
Hepatomegaly
Delayed puberty
Short stature
Tall stature
Decreased body mass index
Increased body mass index
Failure to thrive
Small for gestational age
Weight loss
Obesity
Growth delay
Intrauterine growth retardation
Disease(s) Associated with TNF
beta thalassemia
coronary artery disease
cystic fibrosis
Gaucher's disease
Graves' disease
hemochromatosis
hypochromic microcytic anemia
multiple myeloma
pre-eclampsia
rheumatoid arthritis
systemic lupus erythematosus

Mouse Phenotypes
increased heart weight
alveolar process atrophy
decreased embryo size
increased body mass index
decreased body weight
weight loss
increased body weight
increased body length
decreased susceptibility to diet-induced obesity
increased susceptibility to diet-induced obesity
enlarged liver
increased liver weight
enlarged spleen
increased spleen weight
Availability Mouse Genotype
Lta/Tnftm1Eug/Lta/Tnftm1Eug
Lta/Tnftm1Jods/Lta/Tnftm1Jods
Tnfem4Boui/Tnfem4Boui
Tnftm1Gkl/Tnftm1Gkl
Tnftm2Gkl/Tnftm2Gkl
Tnftm2Gkl/Tnf+
Tnftm2.1Gkl/Tnftm2.1Gkl
Lyz2tm1(cre)Ifo/Lyz2+  (conditional)
Tnftm2.1Gkl/Tnf+
Lyz2tm1(cre)Ifo/Lyz2+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory