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Symbol
Name
ID
Myo6
myosin VI
MGI:104785
Phenotype annotations related to hearing/vestibular/ear
Darker colors indicate more annotations
Human Phenotypes
Sensorineural hearing impairment
Bilateral sensorineural hearing impairment
Progressive sensorineural hearing impairment
Vestibular dysfunction
Disease(s) Associated with MYO6
autosomal dominant nonsyndromic deafness 22
autosomal recessive nonsyndromic deafness 37

Mouse Phenotypes
abnormal outer hair cell kinocilium morphology
abnormal cochlear hair cell development
abnormal cochlear sensory epithelium morphology
abnormal cochlear hair cell stereociliary bundle morphology
abnormal inner hair cell stereociliary bundle morphology
abnormal orientation of inner hair cell stereociliary bundles
decreased inner hair cell stereocilia number
fused inner hair cell stereocilia
abnormal orientation of outer hair cell stereociliary bundles
decreased outer hair cell stereocilia number
fused outer hair cell stereocilia
decreased cochlear hair cell stereocilia number
cochlear inner hair cell degeneration
cochlear outer hair cell degeneration
cochlear hair cell degeneration
absent organ of Corti
organ of Corti degeneration
stria vascularis degeneration
detached tectorial membrane
cochlear degeneration
decreased vestibular hair cell number
abnormal vestibular hair cell stereociliary bundle morphology
fused vestibular hair cell stereocilia
vestibular hair cell degeneration
abnormal crista ampullaris neuroepithelium morphology
abnormal inner ear vestibule morphology
utricular macular degeneration
vestibular saccular macula degeneration
abnormal otolithic membrane morphology
increased or absent threshold for auditory brainstem response
absent cochlear nerve compound action potential
impaired hearing
deafness
abnormal vestibular system physiology
absent linear vestibular evoked potential
reduced linear vestibular evoked potential
Availability Mouse Genotype
Myo6chl/Myo6chl
Myo6mpc285H/Myo6mpc285H
Myo6rsv/Myo6rsv
Myo6sv-2J/Myo6sv-2J
Myo6sv-4J/Myo6sv-4J
Myo6sv/Myo6sv
Myo6twt/Myo6twt
Myo6Mhdatlc/Myo6+
Myo6sv/Myo6+

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory