Symbol
Name
ID

Myo6
myosin VI
MGI:104785

Phenotype annotations related to hearing/vestibular/ear

Darker colors indicate more annotations

Human Phenotypes	Abnormal vestibular function	Sensorineural hearing impairment	Progressive sensorineural hearing impairment
Disease(s) Associated with MYO6	Abnormal vestibular function	Sensorineural hearing impairment	Progressive sensorineural hearing impairment
autosomal dominant nonsyndromic deafness 22
autosomal recessive nonsyndromic deafness 37

Mouse Phenotypes

abnormal kinocilium morphology

abnormal outer hair cell kinocilium morphology

abnormal cochlear hair cell development

abnormal cochlear sensory epithelium morphology

abnormal cochlear hair cell stereociliary bundle morphology

abnormal inner hair cell stereociliary bundle morphology

abnormal orientation of inner hair cell stereociliary bundles

decreased inner hair cell stereocilia number

fused inner hair cell stereocilia

abnormal orientation of cochlear hair cell stereociliary bundles

abnormal orientation of outer hair cell stereociliary bundles

decreased outer hair cell stereocilia number

fused outer hair cell stereocilia

decreased cochlear hair cell stereocilia number

cochlear inner hair cell degeneration

cochlear outer hair cell degeneration

cochlear hair cell degeneration

abnormal cuticular plate morphology

absent organ of Corti

organ of Corti degeneration

stria vascularis degeneration

detached tectorial membrane

cochlear degeneration

decreased vestibular hair cell number

abnormal vestibular hair cell stereociliary bundle morphology

fused vestibular hair cell stereocilia

vestibular hair cell degeneration

abnormal crista ampullaris neuroepithelium morphology

abnormal inner ear vestibule morphology

utricular macular degeneration

vestibular saccular macula degeneration

abnormal otolithic membrane morphology

abnormal auditory brainstem response

abnormal auditory brainstem response waveform shape

increased or absent threshold for auditory brainstem response

absent cochlear nerve compound action potential

impaired hearing

deafness

abnormal vestibular system physiology

absent linear vestibular evoked potential

reduced linear vestibular evoked potential

Availability

Mouse Genotype

Myo6^chl/Myo6^chl

Myo6^em1(IMPC)Tcp/Myo6^em1(IMPC)Tcp

Myo6^em1Bcgen/Myo6^em1Bcgen

Myo6^ksv/Myo6^ksv

Myo6^mpc285H/Myo6^mpc285H

Myo6^rsv/Myo6^rsv

Myo6^sv-2J/Myo6^sv-2J

Myo6^sv-4J/Myo6^sv-4J

Myo6^sv/Myo6^sv

Myo6^twt/Myo6^twt

Myo6^em1Bcgen/Myo6⁺

Myo6^Mhdatlc/Myo6⁺

Myo6^sv/Myo6⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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