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Symbol
Name
ID
Ppara
peroxisome proliferator activated receptor alpha
MGI:104740
Phenotype annotations related to homeostasis/metabolism
Darker colors indicate more annotations
Human Phenotypes
Increased LDL cholesterol concentration
Hypercholesterolemia
Hypertriglyceridemia
Glucose intolerance
Diabetes mellitus
Type II diabetes mellitus
Impaired glucose tolerance
Disease(s) Associated with PPARA
coronary artery disease

Mouse Phenotypes
decreased fatty acid oxidation
increased susceptibility to diet-induced obesity
impaired adaptive thermogenesis
abnormal circulating glucose level
decreased circulating glucose level
hypoglycemia
abnormal circulating insulin level
increased circulating insulin level
abnormal circulating ketone body level
abnormal circulating HDL cholesterol level
increased circulating cholesterol level
increased circulating free fatty acids level
increased circulating triglyceride level
abnormal glucose homeostasis
improved glucose tolerance
decreased liver glycogen level
increased insulin sensitivity
insulin resistance
increased skeletal muscle triglyceride level
delayed wound healing
Availability Mouse Genotype
Pparatm1Gonz/Pparatm1Gonz

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory