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Symbol
Name
ID
Vegfa
vascular endothelial growth factor A
MGI:103178
Phenotype annotations related to skeleton
Darker colors indicate more annotations
Human Phenotypes
Coronal craniosynostosis
Decreased calvarial ossification
Micrognathia
Malar flattening
Brachydactyly
Medial calcification of large arteries
Medial calcification of medium-sized arteries
Joint hypermobility
Bone pain
Pathologic fracture
Bent long bone
Hypoplastic pubic bone
Abnormal thorax morphology
Short clavicles
Bell-shaped thorax
Abnormal sternum morphology
Kyphosis
Scoliosis
Vertebral compression fracture
Osteopenia
Cerebral calcification
Calcification of falx cerebri
Disease(s) Associated with VEGFA
multiple myeloma
pre-eclampsia
pseudoxanthoma elasticum

Mouse Phenotypes
abnormal coronal suture morphology
absent incisors
abnormal mandible morphology
short mandible
abnormal maxilla morphology
abnormal long bone morphology
abnormal long bone diaphysis morphology
decreased width of hypertrophic chondrocyte zone
abnormal rib morphology
scoliosis
abnormal bone structure
abnormal bone marrow cavity morphology
abnormal bone ossification
abnormal intramembranous bone ossification
Availability Mouse Genotype
Vegfatm1Pec/Vegfatm1Pec
Vegfatm2Pec/Vegfatm2Pec
Vegfatm2Gne/Vegfatm2Gne
E2f1Tg(Wnt1-cre)2Sor/E2f1+  (conditional)
Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+
Tg(Col2a1-cre)1Bhr/0  (conditional)
Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory