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Symbol
Name
ID
Stat1
signal transducer and activator of transcription 1
MGI:103063
Phenotype annotations related to hematopoietic system
Darker colors indicate more annotations
Human Phenotypes
Abnormality of blood and blood-forming tissues
Autoimmune hemolytic anemia
Hypereosinophilia
Lymphopenia
Disease(s) Associated with STAT1
chronic mucocutaneous candidiasis

Mouse Phenotypes
abnormal osteoclast differentiation
abnormal common myeloid progenitor cell morphology
abnormal T cell differentiation
abnormal CD4-positive T cell differentiation
abnormal CD8-positive, alpha-beta T cell differentiation
increased basophil cell number
decreased mean corpuscular volume
increased neutrophil cell number
decreased B-1 B cell number
decreased B cell number
decreased NK cell number
increased effector memory CD4-positive, alpha-beta T cell number
increased CD4-positive, alpha beta T cell number
increased effector memory CD8-positive, alpha-beta T cell number
abnormal CD8-positive, naive alpha-beta T cell number
decreased CD8-positive, naive alpha-beta T cell number
decreased CD8-positive, alpha-beta T cell number
increased NK T cell number
decreased single-positive T cell number
increased T cell number
decreased lymphocyte cell number
increased lymphocyte cell number
increased osteoclast cell number
abnormal leukocyte physiology
increased IgG level
abnormal NK cell physiology
decreased NK cell degranulation
impaired natural killer cell mediated cytotoxicity
abnormal T-helper 2 physiology
decreased cytotoxic T cell cytolysis
abnormal T cell activation
abnormal macrophage physiology
abnormal MHC II cell surface expression on macrophages
increased macrophage nitric oxide production
Availability Mouse Genotype
Stat1fae/Stat1fae
Stat1m1Btlr/Stat1m1Btlr
Stat1m2Btlr/Stat1m2Btlr
Stat1m3Btlr/Stat1m3Btlr
Stat1m4Btlr/Stat1m4Btlr
Stat1m5Btlr/Stat1m5Btlr
Stat1tm1Dlv/Stat1tm1Dlv
Stat1tm1Rds/Stat1tm1Rds
Stat1tm1Tdec/Stat1tm1Tdec
Stat1tm1Uvin/Stat1tm1Uvin
Stat1tm2b(EUCOMM)Wtsi/Stat1tm2b(EUCOMM)Wtsi

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory