Symbol
Name
ID

Stat3
signal transducer and activator of transcription 3
MGI:103038

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgE level	Elevated circulating C-reactive protein concentration	Elevated erythrocyte sedimentation rate	Type II diabetes mellitus	Insulin resistance	Joint swelling	Pleural empyema	Fever	Decreased level of D-mannose in urine
Disease(s) Associated with STAT3	Increased circulating IgE level	Elevated circulating C-reactive protein concentration	Elevated erythrocyte sedimentation rate	Type II diabetes mellitus	Insulin resistance	Joint swelling	Pleural empyema	Fever	Decreased level of D-mannose in urine
Behcet's disease
hyper IgE recurrent infection syndrome 1
rheumatoid arthritis
type 2 diabetes mellitus

Mouse Phenotypes

impaired adaptive thermogenesis

decreased circulating glucose level

increased circulating glucose level

hyperglycemia

decreased circulating adrenaline level

increased circulating corticosterone level

decreased circulating insulin level

increased circulating insulin level

abnormal circulating insulin-like growth factor I level

increased circulating leptin level

decreased circulating noradrenaline level

increased circulating triglyceride level

increased circulating interferon-gamma level

increased circulating interleukin-17 level

increased circulating tumor necrosis factor level

abnormal atrial thrombosis

decreased body temperature

abnormal body temperature homeostasis

decreased energy expenditure

generalized edema

ascites

increased oxygen consumption

abnormal glucose homeostasis

impaired glucose tolerance

improved glucose tolerance

insulin resistance

decreased circulating adiponectin level

decreased growth hormone level

abnormal cytokine level

abnormal interleukin level

decreased urine protein level

decreased NAD(P)H oxidase activity

decreased incidence of tumors by chemical induction

increased physiological sensitivity to xenobiotic

increased incidence of tumors by chemical induction

impaired wound healing

increased susceptibility to injury

Availability

Mouse Genotype

Stat3^tm1Dnl/Stat3^tm1Dlv

Gt(ROSA)26Sor^{tm1(Stat3*A661C*N663C)Sbkv}/Gt(ROSA)26Sor^{tm1(Stat3*A661C*N663C)Sbkv}
Tg(Agrp-cre)1Gsb/? (conditional)

Gt(ROSA)26Sor^{tm1(Stat3*A661C*N663C)Sbkv}/Gt(ROSA)26Sor^{tm1(Stat3*A661C*N663C)Sbkv}
Tg(Cd4-cre)1Cwi/0 (conditional)

Stat3^tm1Aki/Stat3^tm1Aki
Tg(Tek-cre)12Flv/0 (conditional)

Stat3^tm1Flv/Stat3^tm1Flv
Tg(Tek-cre)12Flv/0 (conditional)

Stat3^tm1Flv/Stat3^tm1Flv
Tg(Nes-cre)1Kln/0 (conditional)

Stat3^tm1Jbha/Stat3^tm1Jbha
Tg(Fabp4-cre)1Rev/0 (conditional)

Stat3^tm1Vpo/Stat3^tm1Vpo
Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ (conditional)

Stat3^tm1Vpo/Stat3^tm1Vpo
Tg(Myh6-cre)2182Mds/0 (conditional)

Stat3^tm2Aki/Stat3^tm2Aki
Tg(Alb1-cre)1Dlr/0 (conditional)

Stat3^tm2Aki/Stat3^tm2Aki (conditional)

Stat3^tm2Aki/Stat3^tm2Aki
Tg(KRT5-cre/ERT2)AJdg/0 (conditional)

Stat3^tm2Aki/Stat3^tm2Aki
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0 (conditional)

Stat3^tm2Aki/Stat3^tm2Aki
Tg(KRT5-cre)1Tak/0 (conditional)

Stat3^tm1Aki/Stat3^tm2Aki
Tg(NEFL-cre)50Msd/0 (conditional)

Stat3^tm1Vpo/Stat3⁺
Tg(Myh6-cre)2182Mds/0 (conditional)

Stat3^tm1Xyfu/Stat3^tm1.1Xyfu
Tg(Myh6-cre)2182Mds/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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