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Symbol
Name
ID
Guca1a
guanylate cyclase activator 1a (retina)
MGI:102770
Phenotype annotations related to vision/eye
Darker colors indicate more annotations
Human Phenotypes
Macular atrophy
Cone/cone-rod dystrophy
Photophobia
Reduced visual acuity
Progressive visual loss
Disease(s) Associated with GUCA1A
cone-rod dystrophy 14

Mouse Phenotypes
decreased retinal photoreceptor cell number
decreased retinal cone cell number
abnormal photoreceptor outer segment morphology
short photoreceptor outer segment
retinal photoreceptor degeneration
abnormal retina morphology
thin retinal outer nuclear layer
decreased a wave amplitude
decreased b wave amplitude
abnormal eye electrophysiology
abnormal cone electrophysiology
abnormal rod electrophysiology
decreased visual acuity
Availability Mouse Genotype
Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc
Guca1atm1.1Hunt/Guca1atm1.1Hunt
Guca1atm1Itl/Guca1atm1Itl
Guca1a/Guca1btm1Jnc/Guca1a+
Guca1atm1.1Hunt/Guca1a+
Tg(Guca1a*L151F)#Wbae/0
Tg(Guca1a*L151F/EGFP)#Wbae/0

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory