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Symbol
Name
ID
Cav1
caveolin 1, caveolae protein
MGI:102709
Phenotype annotations related to cardiovascular system
Darker colors indicate more annotations
Human Phenotypes
Abnormal cardiovascular system physiology
Elevated right atrial pressure
Right ventricular failure
Heart murmur
Tricuspid regurgitation
Hypertension
Elevated pulmonary artery pressure
Pulmonary arterial hypertension
Increased pulmonary vascular resistance
Elevated jugular venous pressure
Arrhythmia
Palpitations
Angina pectoris
Syncope
Right ventricular dilatation
Right ventricular hypertrophy
Pulmonary arterial medial hypertrophy
Pulmonary aterial intimal fibrosis
Arterial intimal fibrosis
Hepatosplenomegaly
Splenomegaly
Pulmonary artery vasoconstriction
Telangiectasia
Disease(s) Associated with CAV1
congenital generalized lipodystrophy type 3
primary pulmonary hypertension

Mouse Phenotypes
abnormal pulmonary endothelial cell surface
abnormal vascular endothelial cell morphology
abnormal brain vasculature morphology
abnormal lung vasculature morphology
abnormal myocardium layer morphology
abnormal myocardial fiber morphology
heart left ventricle hypertrophy
heart right ventricle hypertrophy
thick interventricular septum
thin interventricular septum
cardiac hypertrophy
dilated heart left ventricle
dilated heart right ventricle
thick ventricular wall
thin ventricular wall
cardiac fibrosis
dilated cardiomyopathy
pulmonary hyperemia
increased vascular permeability
abnormal vasoconstriction
decreased vasoconstriction
abnormal vasodilation
increased vasodilation
abnormal vascular wound healing
decreased cardiac muscle contractility
decreased ventricle muscle contractility
pulmonary hypertension
increased systemic arterial blood pressure
congestive heart failure
Availability Mouse Genotype
Cav1tm1Krc/Cav1tm1Krc
Cav1tm1Kur/Cav1tm1Kur
Cav1tm1Mls/Cav1tm1Mls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory