Symbol
Name
ID

Mmp14
matrix metallopeptidase 14 (membrane-inserted)
MGI:101900

Phenotype annotations related to skeleton

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Osteolysis involving tarsal bones	Broad metacarpals	Carpal osteolysis	Kyphosis	Generalized osteoporosis	Arthropathy
Disease(s) Associated with MMP14
Winchester syndrome

Mouse Phenotypes

skeleton phenotype

increased bone marrow adipose tissue amount

impaired osteoblast differentiation

abnormal cranial suture morphology

abnormal cranium morphology

abnormal Meckel's cartilage morphology

small cranial cavity

abnormal cranial vertex morphology

decreased cranium height

decreased cranium length

decreased cranium width

abnormal neurocranium morphology

abnormal fontanelle morphology

abnormal interparietal bone morphology

abnormal parietal bone morphology

abnormal orbit morphology

abnormal incisor morphology

short lower incisors

abnormal upper incisor morphology

short upper incisors

short incisors

abnormal tooth development

delayed tooth eruption

malocclusion

small mandible

short mandible

short maxilla

domed cranium

abnormal osteoclast physiology

arthritis

short humerus

abnormal long bone morphology

abnormal long bone epiphyseal plate morphology

abnormal long bone epiphyseal plate proliferative zone

increased width of hypertrophic chondrocyte zone

decreased length of long bones

abnormal axial skeleton morphology

kyphosis

lordosis

decreased bone mineral density

abnormal trabecular bone morphology

osteoporosis

abnormal cartilage morphology

abnormal cartilage development

abnormal chondrocyte morphology

abnormal joint morphology

abnormal skeleton development

abnormal skeleton physiology

abnormal bone ossification

abnormal bone mineralization

delayed endochondral bone ossification

delayed intramembranous bone ossification

delayed cranial suture closure

delayed bone ossification

abnormal bone remodeling

Availability

Mouse Genotype

Mmp14^m1Btlr/Mmp14^m1Btlr

Mmp14^sabe/Mmp14^sabe

Mmp14^tm1Hbh/Mmp14^tm1Hbh

Mmp14^tm1Ktry/Mmp14^tm1Ktry

Mmp14^tm1Ski/Mmp14^tm1Ski

Mmp14^tm1Stjw/Mmp14^tm1Stjw
Twist2^{tm1.1(cre)Dor}/Twist2⁺ (conditional)

Mmp14^tm1Stjw/Mmp14^tm1Stjw
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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