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Mouse Models of Parkinson's disease
Mouse Models All mouse models of Parkinson's disease (Disease Ontology ID: DOID:14330)

        Allelic Composition Genetic Background Reference Phenotypes
      autosomal dominant Parkinson disease 1 Sncatm1Rosl/Sncatm1Rosl
Tg(SNCA*A30P)192Rwm/0
B6.Cg-Sncatm1Rosl Tg(SNCA*A30P)#Rwm J:201961 View
autosomal dominant Parkinson disease 1 Sncatm1Rosl/Sncatm1Rosl
Tg(SNCA)OVX37Rwm/0
B6.Cg-Tg(SNCA)OVX37Rwm Sncatm1Rosl J:201991 View
autosomal dominant Parkinson disease 1 Tg(THY1-SNCA*A53T)M53Sud/0 B6.Cg-Tg(THY1-SNCA*A53T)M53Sud/J J:212732 View
autosomal dominant Parkinson disease 1 Tg(SNCA)ARyot/0 C57BL/6J-Tg(SNCA)ARyot J:185434 View
autosomal dominant Parkinson disease 1 Sncatm1.1Koks/Snca+ either: B6.129P2-Sncatm1.1Koks or (involves: 129P2/OlaHsd * C57BL/6) J:201391 View
autosomal dominant Parkinson disease 1 Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo
Tg(Th-cre)1Tmd/0
involves: 129 * C57BL/6 J:150777 View
autosomal dominant Parkinson disease 1 Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo
Tg(Th-cre)1Tmd/0
involves: 129 * C57BL/6 * SJL J:150777 View
autosomal dominant Parkinson disease 1 Sncatm1Nbm/Sncatm1Nbm
Tg(SNCA*A30P)1Nbm/Tg(SNCA*A30P)1Nbm
Tg(SNCA*A30P)2Nbm/Tg(SNCA*A30P)2Nbm
involves: 129S6/SvEvTac * FVB/N J:156741 View
autosomal dominant Parkinson disease 1 Sncatm1Nbm/Sncatm1Nbm
Tg(SNCA*A53T)1Nbm/Tg(SNCA*A53T)1Nbm
Tg(SNCA*A53T)2Nbm/Tg(SNCA*A53T)2Nbm
involves: 129S6/SvEvTac * FVB/N J:156741 View
autosomal dominant Parkinson disease 1 Sncatm1Rosl/Sncatm1Rosl involves: 129X1/SvJ * C57BL/6 J:60151 View
autosomal dominant Parkinson disease 1 Tg(Prnp-SNCA*A53T)83Vle/0 involves: C3H * C57BL/6 J:76657 View
autosomal dominant Parkinson disease 1 Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle involves: C3H * C57BL/6 J:76657 View
autosomal dominant Parkinson disease 1 Tg(Th-SNCA*)1702Yosh/0 involves: C3H * C57BL/6J J:125149 View
autosomal dominant Parkinson disease 1 Tg(Prnp-SNCA*A53T)23Mkle/0 involves: C3H/HeJ * C57BL/6J J:77344 View
autosomal dominant Parkinson disease 1 Tg(Prnp-SNCA*A53T)25Mkle/0 involves: C3H/HeJ * C57BL/6J J:77344 View
autosomal dominant Parkinson disease 1 Tg(Thy1-SNCA*A30P)18Pjk/Tg(Thy1-SNCA*A30P)18Pjk involves: C57BL/6 J:80181 View
autosomal dominant Parkinson disease 1 Tg(PDGFB-SNCA)4Ema/0 involves: C57BL/6 * DBA/2 J:60638, J:166985 View
autosomal dominant Parkinson disease 1 Tg(Thy1-SNCA)61Ema/0 involves: C57BL/6 * DBA/2 J:137490 View
autosomal dominant Parkinson disease 1 Tg(Snca-SNCA)#Galt/? involves: C57BL/6 * DBA/2 J:199939 View
autosomal dominant Parkinson disease 1 Tg(SNCA*E46K)3Elan/? involves: C57BL/6 * SJL J:200740 View
autosomal dominant Parkinson disease 1 Tg(Prnp-SNCA*A53T)AAub/? involves: FVB/N J:216589 View
autosomal dominant Parkinson disease 1 Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub involves: FVB/N J:181820, J:185489 View
autosomal dominant Parkinson disease 1 Tg(PDGFB-SNCA*A53T)8Ema/0 Not Specified J:226922 View
autosomal dominant Parkinson disease 4 Tg(Thy1-Snca)1S13Putt/? involves: C57BL/6 J:177661 View
autosomal dominant Parkinson disease 8 Tg(LRRK2*R1441G)135Cjli/0 FVB-Tg(LRRK2*R1441G)135Cjli J:149135 View
autosomal dominant Parkinson disease 8 Tg(LRRK2*R1441G)135Cjli/0 FVB/N-Tg(LRRK2*R1441G)135Cjli/J J:204940 View
autosomal dominant Parkinson disease 8 Tg(PDGFB-LRRK2*G2019S)32Hlw/? FVB/N-Tg(PDGFB-LRRK2*G2019S)32Hlw J:204793 View
autosomal dominant Parkinson disease 8 Tg(PDGFB-LRRK2*R1441C)31Hlw/0 FVB/N-Tg(PDGFB-LRRK2*R1441C)31Hlw J:229559 View
autosomal dominant Parkinson disease 8 Tg(Lrrk2*G2019S)2Yue/0 involves: C3H * C57BL/6 * C57BL/6J J:157931 View
autosomal recessive early-onset Parkinson disease 6 Pink1tm1.1Wrst/Pink1tm1.1Wrst involves: 129S2/SvPas * BALB/cJ * C57BL/6J J:183290 View
autosomal recessive early-onset Parkinson disease 6 Pink1tm1Shn/Pink1tm1Shn involves: 129S4/SvJae * C57BL/6 J:122728 View
autosomal recessive early-onset Parkinson disease 6 Pink1tm1Hbu/Pink1tm1Hbu involves: 129S7/SvEvBrd * C57BL/6 J:169471 View
autosomal recessive early-onset Parkinson disease 6 Pink1tm1Aub/Pink1tm1Aub involves: 129S/SvEv J:150206 View
autosomal recessive early-onset Parkinson disease 7 Park7tm1Dsp/Park7tm1Dsp B6.129P2-Park7tm1Dsp J:190315 View
autosomal recessive early-onset Parkinson disease 7 Park7tm1Shn/Park7tm1Shn involves: 129 * C57BL/6 J:98436 View
autosomal recessive early-onset Parkinson disease 7 Park7tm1Xz/Park7tm1Xz involves: 129P2/OlaHsd * C57BL/6J J:99905 View
autosomal recessive early-onset Parkinson disease 7 Park7tm1Cai/Park7tm1Cai involves: 129X1/SvJ * C57BL/6 J:141628 View
autosomal recessive juvenile Parkinson disease 2 Park2tm1Roo/Park2tm1Roo either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6) J:85561 View
autosomal recessive juvenile Parkinson disease 2 Tg(Slc6a3-PARK2*Q311X)AXwy/0 FVB/NJ-Tg(Slc6a3-PARK2*Q311X)AXwy J:146833 View
autosomal recessive juvenile Parkinson disease 2 Park2tm1Ykt/Park2tm1Ykt
Tg(Prp-GPR37)1Ryot/0
involves: 129P2/OlaHsd * C3H * C57BL/6 J:140326 View
autosomal recessive juvenile Parkinson disease 2 Park2tm1Ykt/Park2tm1Ykt
Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
involves: 129P2/OlaHsd * C3H * C57BL/6 J:140326 View
autosomal recessive juvenile Parkinson disease 2 Park2tm1Ykt/Park2tm1Ykt
Tg(PDGFB-GPR37)20Ryot/0
involves: 129P2/OlaHsd * C57BL/6 J:140326 View
autosomal recessive juvenile Parkinson disease 2 Park2tm1Ykt/Park2tm1Ykt
Tg(PDGFB-GPR37)20Ryot/Tg(PDGFB-GPR37)20Ryot
involves: 129P2/OlaHsd * C57BL/6 J:140326 View
autosomal recessive juvenile Parkinson disease 2 Park2tm1Ccs/Park2tm1Ccs involves: 129S1/Sv * 129X1/SvJ * C57BL/6J J:168847 View
autosomal recessive juvenile Parkinson disease 2 Park2tm1Roo/Park2tm1Roo involves: 129S2/SvPas J:125148 View
autosomal recessive juvenile Parkinson disease 2 Park2tm1Shn/Park2tm1Shn involves: 129S4/SvJae J:86377 View
autosomal recessive juvenile Parkinson disease 2 Park2tm1Tmd/Park2tm1Tmd involves: C57BL/6 J:91487 View
Kufor-Rakeb syndrome Atp13a2tm1.2Wtd/Atp13a2tm1.2Wtd involves: 129 * C57BL/6 J:221680 View
Parkinson disease 17 Vps35Gt(RRK261)Byg/Vps35+ B6.129P2-Vps35Gt(RRK261)Byg J:225806 View
Parkinson's disease Htra2mnd2/Htra2mnd2 B6.Cg-Htra2mnd2 J:85268, J:125616 View
Parkinson's disease Uchl1gad-2J/Uchl1gad-2J B6.Cg-Uchl1gad-2J/GrsrJ J:222308 View
Parkinson's disease Htra2tm1Jdo/Htra2tm1Jdo involves: 129P/Ola * C57BL/6 J:94227 View
Parkinson's disease Htra2tm1Jdo/Htra2tm1Jdo
Diablotm1Mak/Diablotm1Mak
involves: 129P/Ola * C57BL/6 J:94227 View
Parkinson's disease Tg(PDGFB-UCHL1*I93M)HWada/? involves: C57BL/6J J:128045 View
      Parkinson's disease Adh7tm1Gdu/Adh7tm1Gdu B6.129(Cg)-Adh7tm1Gdu J:167234 View
Parkinson's disease Cox10tm1Ctm/Cox10tm1Ctm
Slc6a3tm1.1(cre)Bkmn/?
B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn J:231810 View
Parkinson's disease Slc6a3tm1(cre)Lrsn/Slc6a3+
Tfamtm1Lrsn/Tfamtm1Lrsn
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL J:119515 View
Parkinson's disease Atg7tm1Tchi/Atg7tm1Tchi
En1tm2(cre)Wrst/En1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj J:192452 View
Parkinson's disease Atg7tm1Tchi/Atg7tm1Tchi
Slc6a3tm1(cre)Xz/Slc6a3+
involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj J:192452 View
Parkinson's disease Sprtm1Lex/Sprtm1Lex involves: 129S/SvEvBrd * C57BL/6J J:131376 View
Parkinson's disease Tg(Th-Twnk*,-EGFP)2Gcor/0 involves: C57BL/6J J:188914 View
Transgenes and
Other Mutations
     autosomal dominant Parkinson disease 1 Tg(Thy1-SNCA*E57K)16Ema/0 involves: C57BL/6 * DBA/2 J:236596 View
autosomal dominant Parkinson disease 1 Tg(PDGFB-SNCA/EGFP)78Ema/0 involves: C57BL/6 * DBA/2 J:238692 View
Parkinson's disease Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-SNCA)0Olri/0
involves: C57BL/6 J:132774 View
Parkinson's disease Tg(CAG-SNCA*)1.1Ccs/? involves: C57BL/6 J:168847 View
Parkinson's disease Tg(Th-SNCA*)1.2Ccs/? involves: C57BL/6 J:168847 View
Parkinson's disease Tg(Snca-SNCA/GFP)#Jyl/Tg(Snca-SNCA/GFP)#Jyl involves: C57BL/6 J:197984 View
Parkinson's disease Tg(GFAP-tTA)#Hyms/0
Tg(tetO-HMOX1)#Hyms/0
involves: FVB J:190573 View
Additional Complex Models     Parkinson's disease Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+
Mfn2tm3Dcc/Mfn2tm3Dcc
Slc6a3tm1.1(cre)Bkmn/Slc6a3+
involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J J:188347 View
Parkinson's disease Lmx1atm1Tpe/Lmx1atm1Tpe
Lmx1btm1Zfc/Lmx1btm1Zfc
Slc6a3tm1(cre)Lrsn/Slc6a3+
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 J:222854 View
Parkinson's disease En1tm2Alj/En1+
Tg(Th-EGFP)6-7Okn/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J * OF1 J:214073 View
Parkinson's disease Slc6a3tm2(tTA)Xz/Slc6a3+
Tg(tetO-COX8A/PstI*)1Ctm/0
involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL J:178139 View
Disease phenotype
not observed
No similarity to the expected human disease phenotype was found.

        Allelic Composition Genetic Background Reference Phenotypes
NOT Models     Parkinson's disease Tg(Prnp-HTRA2*G399S)1Olri/0 involves: C57BL/6 J:229160 View

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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory