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Mouse Models of Diabetes Mellitus, Insulin-Dependent; IDDM
Mouse Models All mouse models of Diabetes Mellitus, Insulin-Dependent; IDDM (OMIM ID: 222100)

        Allelic Composition Genetic Background Reference Phenotypes
      Cd38tm1Lnd/Cd38tm1Lnd NOD.129P2(B6)-Cd38tm1Lnd/LtJ J:108097 View
Cdk4tm1Bbd/Cdk4tm1Bbd involves: 129S1/Sv * 129X1/SvJ * ICR J:54534 View
E2f1tm1Meg/E2f1tm1Meg NOD.Cg-E2f1tm1Meg J:93708 View
Faslpr/Faslpr
Tg(Ins2-Fasl)24Ach/0
NOD.Cg-Faslpr Tg(Ins2-Fasl)24Ach J:81416 View
Fastm1Vbo/Fastm1Vbo
Tg(Ins2-cre)25Mgn/0
Tg(Ins2-HA)165Bri/0
Tg(Tcra/Tcrb)1Vbo/0
Not Specified J:85985 View
Foxo1tm1Whb/Foxo1+
Pdpk1tm1Maka/Pdpk1tm1Maka
Tg(Ins2-cre)23Herr/0
involves: 129S4/SvJae * C57BL/6J * CBA/J J:109224 View
Gad2tm1Miya/Gad2tm1Miya NOD.129P2-Gad2tm1Miya J:88785 View
Ifngtm1Ts/Ifngtm1Ts NOD.129S7(B6)-Ifngtm1Ts Prkdcscid J:72818 View
Ifngtm1Ts/Ifngtm1Ts NOD.129S7(B6)-Ifngtm1Ts/DvsJ J:72818 View
Ifngr2tm1Pbro/Ifngr2tm1Pbro NOD.129S1-Ifngr2tm1Pbro J:72818 View
Ighmtm1Cgn/Ighmtm1Cgn
Tg(Igh-VB1-8/Igh-6m)1Mjsk/?
NODCaj.Cg-Ighmtm1Cgn Tg(Igh-VB1-8/Igh-6m)1Mjsk/FswJ J:93190 View
Ighmtm1Cgn/Ighm+
Tg(Igh-6/Igh-V281)3Jwt/0
NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt J:91865 View
Ighmtm1Cgn/Ighm+ NOD.129S2-Ighmtm1Cgn J:37287 View
Il1r1tm1Roml/Il1r1tm1Roml NOD.Cg-Il1r1tm1Roml J:87251 View
Il4tm1Cgn/Il4tm1Cgn either: NOD.129-Il4tm1Cgn or (involves: 129 * NOD) J:85924 View
Il4tm1Cgn/Il4tm1Cgn
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
NOD.Cg-Il4tm1Cgn Tg(TcraBDC2.5,TcrbBDC2.5)1Doi J:85924 View
H2g7/H2g7
Ins2tm1Jja/Ins2tm1Jja
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD J:111874 View
Ins2Akita/Ins2Akita C.B6N-Ins2Akita J:198186 View
Ins2tm1Jja/Ins2tm1Jja NOD.129S2-Ins2tm1Jja J:85309 View
Ins2Akita/Ins2Akita
Itga1tm1Gdnr/Itga1tm1Gdnr
C.Cg-Ins2Akita Itga1tm1Gdnr J:198186 View
Pdx1tm1Cvw/Pdx1tm4Cvw
Tg(Ins2-cre)25Mgn/0
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA J:130389 View
Prf1tm1Clrk/Prf1tm1Clrk involves: 129S7/SvEvBrd * BALB/c * NOD J:64051 View
Prf1tm1Clrk/Prf1tm1Clrk
Tg(INS-Il10)#Sar/0
involves: 129S7/SvEvBrd * BALB/c * NOD J:64051 View
Ptprn2tm1Aln/Ptprn2tm1Aln involves: 129S4/SvJae * C57BL/6N * NOD/LtJ J:81889 View
Selltm1Flv/Selltm1Flv involves: C57BL/6 * NOD J:88974 View
Selltm1Flv/Selltm1Flv NOD.Cg-Selltm1Flv J:88974 View
Selltm1Flv/Sell+ involves: C57BL/6 * NOD J:88974 View
Selltm1Flv/Sell+ NOD.Cg-Selltm1Flv J:88974 View
Stat4tm1Gru/Stat4tm1Gru C.129S2-Stat4tm1Gru J:106340 View
Stat4tm1Gru/Stat4tm1Gru
Tg(Ins2-NP)25-3Olds/0
involves: 129S2/SvPas * BALB/c * C57BL/6 J:107047 View
Stat4tm1Gru/Stat4tm1Gru
Tg(Ins2-GP)34-20Olds/0
involves: 129S2/SvPas * BALB/c * C57BL/6 J:107047 View
Stat4tm1Gru/Stat4+ NOD.129S2-Stat4tm1Gru J:90600 View
Tnfsf4tm1Shr/Tnfsf4tm1Shr NOD.129S4-Tnfsf4tm1Shr J:86926 View
Transgenes and
Other Mutations
     Tg(H2-Ea-G6pc2)69Tkay/? NOD-Tg(H2-Ea-G6pc2)69Tkay J:117352 View
Tg(H2-Ea-Ins2)1Wehi/0 NOD/ShiLtJWehi-Tg(H2-Ea-Ins2)1Wehi J:100251 View
Tg(H2-Ead)12Lt/0 NOD/ShiLt-Tg(H2-Ead)12Lt J:36435 View
Tg(HLA-A/H2-D/B2M)1Dvs/0 NOD/ShiLtDvs-Tg(HLA-A/H2-D/B2M)1Dvs J:121685 View
B2mtm1Unc/B2mtm1Unc
Tg(HLA-A/H2-D/B2M)1Dvs/0
NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs J:121685 View
Tg(Igh-6/Igh-V281)3Jwt/0 NOD.B6-Tg(Igh-6/Igh-V281)3Jwt J:91865 View
Ighmtm1Cgn/Ighm+
Tg(Igh-6/Igh-V281)3Jwt/0
NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt J:91865 View
Tg(IghelMD4)4Ccg/Tg(IghelMD4)4Ccg NOD.B6-Tg(IghelMD4)4Ccg/DvsJ J:80859 View
Tg(Ins1-Cat,Tyr)25Pne/0 involves: FVB J:59725 View
Tg(Ins1-Cat,Tyr)25Pne/0 NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne J:108415 View
Tg(Ins2*Y16A)3Ell/0 NOD-Tg(Ins2*Y16A)3Ell J:98583 View
Tg(Ins2-CALM1)26Ove/0 FVB-Tg(Ins2-CALM1)26Ove J:94602 View
Tg(Cryaa-TAg)1Ove/0
Tg(Ins2-CALM1)26Ove/0
FVB/N J:97926 View
Tg(Ins2-CD80)3B7Flv/? involves: C57BL/6 * CBA/Ca * NOD/Caj J:26618 View
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(Ins2-CD80)3B7Flv/0
B6.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)1Dv Tg(Ins2-CD80)3B7Flv J:59245 View
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0
involves: 129S2/SvPas * C57BL/6 * CBA * SJL J:68641 View
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0
involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA * SJL J:68641 View
Tg(Ins2-CD86)12B70Flv/0 involves: C57BL/6 * CBA/Ca J:93555 View
Tg(Ins2-Fasl)24Ach/0 NOD-Tg(Ins2-Fasl)24Ach J:78679 View
Tg(Ins2-Fas*I246N)1Ach/0
Tg(Ins2-Fasl)24Ach/0
NOD-Tg(Ins2-Fas*I246N)1Ach Tg(Ins2-Fasl)24Ach J:81416 View
Faslpr/Faslpr
Tg(Ins2-Fasl)24Ach/0
NOD.Cg-Faslpr Tg(Ins2-Fasl)24Ach J:81416 View
Tg(Ins2-GP)34-20Olds/0 involves: BALB/c * C57BL/6 J:81287 View
Stat4tm1Gru/Stat4tm1Gru
Tg(Ins2-GP)34-20Olds/0
involves: 129S2/SvPas * BALB/c * C57BL/6 J:107047 View
Fastm1Vbo/Fastm1Vbo
Tg(Ins2-cre)25Mgn/0
Tg(Ins2-HA)165Bri/0
Tg(Tcra/Tcrb)1Vbo/0
Not Specified J:85985 View
Tg(Ins2-HBEGF)5Rin/? C57BL/6-Tg(Ins2-HBEGF)5Rin J:204420 View
Tg(Ins2-Nos2)31Okam/0 involves: C57BL/6 * CD-1 * DBA/2 J:45520 View
Tg(Ins2-Nos2)40Okam/0 involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2 J:116040 View
Tg(Ins2-Nos2)40Okam/0 involves: C57BL/6 * CD-1 * DBA/2 J:4552 View
Agertm1.1Hyam/Agertm1.1Hyam
Tg(Ins2-Nos2)40Okam/0
involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2 J:116040 View
Tg(Ins2-Nos2)40Okam/0
Tg(Kdr-AGER)102Hyam/0
involves: C57BL/6J * CBA/J * CD-1 * DBA/2 J:70495 View
Tg(Ins2-NP)25-3Olds/0 involves: BALB/c * C57BL/6 J:81284 View
Stat4tm1Gru/Stat4tm1Gru
Tg(Ins2-NP)25-3Olds/0
involves: 129S2/SvPas * BALB/c * C57BL/6 J:107047 View
Tg(INS-MT2A,Tyr)1Pne/0 FVB-Tg(INS-MT2A,Tyr)1Pne J:100251 View
Tg(INS-MT2A,Tyr)1Pne/0 NOD.FVB-Tg(INS-MT2A,Tyr)1Pne J:108415 View
Tg(INS-SOD2)3Pne/0 NOD.FVB-Tg(INS-SOD2)3Pne J:108415 View
Tg(TcraAI4)1Dvs/0 NOD-Tg(TcraAI4)1Dvs J:93553 View
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
NOD-Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs J:93553 View
Cd4tm1Knw/Cd4tm1Knw
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
NOD.Cg-Cd4tm1Knw Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs J:93553 View
Prkdcscid/Prkdcscid
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
NOD.Cg-Prkdcscid Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs J:93553 View
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
NOD.Cg-Rag1tm1Mom Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs J:94192 View
Tg(TcraTcrbNY8.3)1Pesa/? involves: C57BL/6 * NOD * SJL J:44202 View
Additional Complex Models     Tg(Igh-6/Igh-V125)2Jwt/0
Tg(Igk-C/Igk-V125)1Jwt/0
NOD.B6-Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt J:91865 View
Ins1tm1Jja/Ins1tm1Jja
Tg(Ins2*Y16A)1Ell/0
NOD.Cg-Ins1tm1Jja Tg(Ins2*Y16A)1Ell J:98583 View
H2g7/H2g7
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD J:111874 View
H2g7/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD J:111874 View
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD J:111874 View
Prkdcscid/Prkdcscid
Tg(INS-HBEGF*L148S*P149T)70Rin/?
CB17/lcr-Prkdcscid Tg(INS-HBEGF*L148S*P149T)70Rin J:204420 View
Cd80tm1Shr/Cd80tm1Shr
Cd86tm2Shr/Cd86tm2Shr
involves: 129S4/SvJae * NOD J:61905 View
Casp1tm1Sesh/Casp1tm1Sesh
Casp4del/Casp4del
NOD.129S2(B6)-Casp1tm1Sesh Casp4del/LtJ J:87250 View
Tg(Ins1-Cd80)378Psoh/0
Tg(Ins2-GP)#Psoh/0
Tg(TcrLCMV)327Sdz/0
involves: C57BL/6 * DBA/2 * FVB/N J:209714 View
Disease phenotype
not observed
No similarity to the expected human disease phenotype was found.

        Allelic Composition Genetic Background Reference Phenotypes
NOT Models     Faslpr/Faslpr NOD.MRL(B6)-Faslpr J:64051 View
Ighmtm1Cgn/Ighmtm1Cgn NOD.129S2-Ighmtm1Cgn J:37287 View
Ighmtm1Cgn/Ighmtm1Cgn NOD.129S2-Ighmtm1Cgn/DvsJ J:80859 View
Ighmtm1Cgn/Ighmtm1Cgn
Tg(IghelMD4)4Ccg/Tg(IghelMD4)4Ccg
NOD.Cg-Ighmtm1Cgn Tg(IghelMD4)4Ccg/DvsJ J:80859 View
Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja
Tg(Ins2*Y16A)3Ell/0
NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)3Ell J:98583 View
Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja
Tg(Ins2*Y16A)1Ell/0
NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)1Ell J:98583 View
Stat4tm1Gru/Stat4tm1Gru NOD.129S2-Stat4tm1Gru J:90600 View
B2mtm1Unc/B2mtm1Unc
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
NOD.Cg-B2mtm1Unc Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs J:93553 View
Cd4tm1Knw/Cd4tm1Knw NOD.Cg-Cd4tm1Knw J:93553 View
Tlr2tm1Aki/Tlr2tm1Aki NOD.129P2-Tlr2tm1Aki J:124334 View
B2mtm1Jae/B2mtm1Jae
Tg(B2m)1Rms/0
Tg(INS-cre)2Rms/0
involves: 129S2/SvPas * NOD J:83635 View
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell J:87013 View
Tg(TcrbAI4)1Dvs/0 NOD-Tg(TcrbAI4)1Dvs J:93553 View
Icam1tm1Jcgr/Icam1tm1Jcgr
Tg(INS-Il10)#Sar/0
NOD.Cg-Icam1tm1Jcgr Tg(INS-Il10)#Sar J:98583 View
B2mtm1Unc/B2mtm1Unc NOD.129P2-B2mtm1Unc J:17000 View
Ins1tm1Jja/Ins1tm1Jja NOD.129S2-Ins1tm1Jja J:85309 View
Tg(H2-Ead)5Lt/0 NOD/ShiLt-Tg(H2-Ead)5Lt J:36435 View
Ctnna2tm1Mta/Ctnna2tm1Mta Not Specified J:83635 View
Parp1tm1Hsmm/Parp1tm1Hsmm involves: 129S4/SvJae J:53360 View
Casp3tm1Mak/Casp3tm1Mak B6.129P2-Casp3tm1Mak J:97650 View
Ciitatm1Ccum/Ciitatm1Ccum NOD.129S2(B6)-Ciitatm1Ccum J:106081 View
B2mtm1Unc/B2mtm1Unc
Ciitatm1Ccum/Ciitatm1Ccum
NOD.Cg-B2mtm1Unc Ciitatm1Ccum J:107051 View

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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory