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Mouse Models of Alzheimer Disease; AD
Mouse Models All mouse models of Alzheimer Disease; AD (OMIM ID: 104300)

        Allelic Composition Genetic Background Reference Phenotypes
      Apptm1Dbo/Apptm1Dbo involves: 129S7/SvEvBrd * C57BL/6J J:53824 View
Apptm1Cep/Apptm1Cep involves: 129S1/Sv * 129X1/SvJ J:35500 View
Apptm1.1Cep/Apptm1.1Cep involves: 129S1/Sv * 129X1/SvJ J:35500 View
Apptm1Ini/App+ involves: C57BL/6 * CBA * CD-1 J:90296 View
Apptm1Cep/App+ involves: 129S1/Sv * 129X1/SvJ J:35500 View
Apptm1.1Cep/App+ involves: 129S1/Sv * 129X1/SvJ J:35500 View
Apptm1Ck/Apptm1Ck
Psen1tm1Mpm/Psen1tm1Mpm
Tg(MAPT)8cPdav/0
B6.Cg-Psen1tm1Mpm Apptm1Ck Tg(MAPT)8cPdav J:209782 View
Apptm1.1Cep/Apptm1.1Cep
Psen1tm1Dgf/Psen1tm1Dgf
involves: 129S1/Sv * 129X1/SvJ * CD-1 J:102425 View
Apptm1Ck/Apptm1Ck
Psen1tm1Mpm/Psen1tm1Mpm
involves: 129 * 129S1/Sv * 129X1/SvJ J:191170 View
Apptm1Dbo/Apptm1Dbo
Npc1m1N/Npc1m1N
C.Cg-Apptm1Dbo Npc1m1N J:172769 View
Plautm1Mlg/Plautm1Mlg involves: 129S2/SvPas * C57BL/6 J:104962 View
      Cav1tm1Mls/Cav1tm1Mls Not Specified J:168335 View
Lrp1tm2Her/Lrp1tm2Her
Tg(Camk2a-cre)T29-1Stl/0
involves: 129S7/SvEvBrd * BALB/c * C57BL J:167724 View
Lrp1tm2Her/Lrp1tm2Her
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
Tg(Tagln-cre)1Her/0
involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * C57BL/6J * SJL J:192453 View
Mmetm1Cge/Mmetm1Cge involves: 129S4/SvJae * C57BL/6 J:69830 View
Pin1tm1Tuc/Pin1tm1Tuc involves: 129 * 129P2/OlaHsd * C57BL/6 J:107132 View
Pin1tm1Tuc/Pin1tm1Tuc
Tg(APPSWE)2576Kha/0
involves: 129 * 129P2/OlaHsd * C57BL/6 * SJL J:107132 View
Plcb1tm1Hssh/Plcb1tm1Hssh Not Specified J:43077 View
Ppp3catm1Jse/Ppp3catm1Jse either: (involves: 129S4/SvJae * Black Swiss) or (involves: 129S4/SvJae * C57BL/6) J:39103 View
Psen1tm1Bdes/Psen1tm1Bdes involves: 129P2/OlaHsd J:71037 View
Psen1tm1Mpm/Psen1tm1Mpm involves: 129S1/Sv * 129X1/SvJ * C57BL/6 J:51950 View
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/?
B6.Cg-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa J:170670 View
Psen1tm1Tak/Psen1tm1Tak involves: 129S1/Sv * 129X1/SvJ * C57BL/6 J:99353 View
Psen1tm1Shn/Psen1tm1Shn involves: 129S7/SvEvBrd * C57BL/6 J:40365 View
Apptm1Ck/Apptm1Ck
Psen1tm1Mpm/Psen1tm1Mpm
Tg(MAPT)8cPdav/0
B6.Cg-Psen1tm1Mpm Apptm1Ck Tg(MAPT)8cPdav J:209782 View
Psen1tm1Lpr/Psen1tm1Lpr
Tg(Thy1-APPSL)28Lpr/0
either: 129/Sv or (involves: 129/Sv * C57BL/6) J:93770 View
Apptm1.1Cep/Apptm1.1Cep
Psen1tm1Dgf/Psen1tm1Dgf
involves: 129S1/Sv * 129X1/SvJ * CD-1 J:102425 View
Psen1tm1Mpm/Psen1tm1Pcw involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 J:91277 View
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/Tg(APPSwe,tauP301L)1Lfa
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 J:99604 View
Psen1tm1Lpr/Psen1tm1Lpr
Tg(Thy1-APPSL)28Lpr/0
involves: 129 * C57BL/6 * CBA J:128106 View
Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-cre)1Vln/0
involves: FVB/N J:87229 View
Apptm1Ck/Apptm1Ck
Psen1tm1Mpm/Psen1tm1Mpm
involves: 129 * 129S1/Sv * 129X1/SvJ J:191170 View
Psen1tm1Dgf/Psen1tm1Dgf
Tg(APPSWE)2576Kha/?
involves: 129 * C57BL/6 * CD-1 * SJL J:102425 View
Psen1tm1Jzt/Psen1tm1Jzt
Tg(Camk2a-cre)T29-1Stl/0
involves: C57BL/6 * CBA J:73252 View
Psen1tm1Jzt/Psen1tm1Jzt
Psen2tm1Ber/Psen2tm1Ber
Tg(Camk2a-cre)T29-1Stl/0
involves: C57BL/6 * CBA J:90685 View
Psen1tm1Zhe/Psen1tm1Zhe
Tg(APPSWE)2576Kha/?
involves: 129S7/SvEvBrd * C57BL/6 * SJL J:107251 View
Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2+
Tg(Thy1-APP*)2.2Ingm/0
involves: C57BL/6 * DBA/1 J:176575 View
Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2Tg(Thy1-Trh/APP*)2.1Ingm involves: C57BL/6 * DBA/1 J:176575 View
      Sorl1tm1Tew/Sorl1tm1Tew
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
involves: 129 * C3H/HeJ * C57BL/6 J:142501 View
Transgenes and
Other Mutations
     Tg(ACTB-APP*V717F)1Colm/0 involves: C57BL/6 * DBA J:157859 View
Tg(APP695)3Dbo/0 B6.C3-Tg(APP695)3Dbo J:109847 View
Tg(APP695)3Dbo/0 involves: C3H/HeJ * C57BL/6J J:87691 View
Sorl1tm1Tew/Sorl1tm1Tew
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
involves: 129 * C3H/HeJ * C57BL/6 J:142501 View
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
involves: C3H/HeJ * C57BL/6J J:43788 View
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J J:123534 View
Klc1tm1Gsn/Klc1+
Tg(APP695)3Dbo/?
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6 J:96346 View
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
involves: C3H/HeJ * C57BL/6J J:123534 View
Lrp1tm2Her/Lrp1tm2Her
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
Tg(Tagln-cre)1Her/0
involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * C57BL/6J * SJL J:192453 View
Tg(APP)8.9Btla/Tg(APP)8.9Btla involves: 129S2/SvPas J:96742 View
Tg(APPSw)40Btla/Tg(APPSw)40Btla B6.129-Tg(APPSw)40Btla J:86629 View
Tg(APPSw)40Btla/0 involves: 129S1/Sv * 129X1/SvJ J:42613 View
Tg(APPSWE)2576Kha/0 involves: 129S7/SvEvBrd * C57BL/6 * SJL J:114480, J:180385 View
Tg(APPSWE)2576Kha/0 involves: C57BL/6 * DBA/2 * SJL * SW J:174270 View
Tg(APPSWE)2576Kha/0
Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
involves: C57BL/6 * DBA/2 * SJL * SW J:100965 View
Tg(APPSWE)2576Kha/0
Tg(PDGFB-PSEN1M146L)2Jhd/0
involves: C57BL/6 * DBA/2 * SJL * SW J:174270 View
Tg(APPSWE)2576Kha/0 involves: C57BL/6 * SJL J:119251 View
Pin1tm1Tuc/Pin1tm1Tuc
Tg(APPSWE)2576Kha/0
involves: 129 * 129P2/OlaHsd * C57BL/6 * SJL J:107132 View
Psen1tm1Dgf/Psen1tm1Dgf
Tg(APPSWE)2576Kha/?
involves: 129 * C57BL/6 * CD-1 * SJL J:102425 View
Tg(APPSWE)2576Kha/0
Tg(PSEN1)5Dbo/0
involves: C57BL/6 * SJL J:191088 View
Nos2tm1Lau/Nos2tm1Lau
Tg(APPSWE)2576Kha/0
involves: 129P2/OlaHsd * C57BL/6 * SJL J:112919 View
Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Tg(APPSWE)2576Kha/?
involves: 129P2/OlaHsd * C57BL/6 * SJL J:98636 View
Psen1tm1Zhe/Psen1tm1Zhe
Tg(APPSWE)2576Kha/?
involves: 129S7/SvEvBrd * C57BL/6 * SJL J:107251 View
Ldlrtm1Her/Ldlrtm1Her
Tg(APPSWE)2576Kha/0
involves: 129S7/SvEvBrd * C57BL/6 * SJL J:114480 View
Tg(APPswe,PSEN1dE9)85Dbo/0 B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax J:160557, J:172426 View
Tg(APPswe,PSEN1dE9)85Dbo/0 B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax J:113199 View
Tg(APPswe,PSEN1dE9)85Dbo/0 involves: C3H/HeJ * C57BL/6J J:87691, J:113200 View
Leprdb/Lepr+
Tg(APPswe,PSEN1dE9)85Dbo/0
involves: C3H * C57BL/6 * C57BLKS/J J:186924 View
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0 B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax J:214858 View
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0 involves: C57BL/6 * SJL J:112949 View
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Tg(Thy1-MAPT*)30Schd/0
involves: C57BL/6 * C57BL/6J * CBA * SJL J:201809 View
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/? involves: 129S4/SvJae * C57BL/6 * SJL J:169682 View
Apoa4tm1Bres/Apoa4tm1Bres
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
involves: 129S4/SvJae * C57BL/6 * SJL J:169682 View
Tg(APPSwLon)96Btla/0 involves: 129S4/SvJae J:42613 View
Tg(APPV717F)109Ili/Tg(APPV717F)109Ili Not Specified J:78357 View
Tg(APPV717F)109Ili/0 involves: BALB/c * C57BL * C57BL/6NTac J:184975 View
Tg(APPV717F)109Ili/0 Not Specified J:23080 View
Tg(APPV717F)109Ili/0
Tg(Prnp-MAPT*P301S)PS19Vle/0
involves: C3H * C57BL/6 J:165441 View
Apoetm1Unc/Apoetm1Unc
Tg(APPV717F)109Ili/Tg(APPV717F)109Ili
involves: 129P2/OlaHsd J:107702 View
Apoetm1Unc/Apoetm1Unc
Clutm1Jakh/Clutm1Jakh
Tg(APPV717F)109Ili/Tg(APPV717F)109Ili
involves: 129P2/OlaHsd * 129S2/SvPas J:107702 View
Clutm1Jakh/Clutm1Jakh
Tg(APPV717F)109Ili/Tg(APPV717F)109Ili
involves: 129S2/SvPas J:78357 View
Msr1tm1Csk/Msr1tm1Csk
Tg(APPV717F)109Ili/?
involves: 129X1/SvJ * C57BL/6 * DBA/2 * ICR J:58338 View
Tg(Camk2a-App*,-Apbb1)25Spim/0 C57BL/6-Tg(Camk2a-App*,-Apbb1)25Spim J:153738 View
Tg(CMV-IgkvaD11)BCat/Tg(CMV-IgkvaD11)BCat involves: 129 * C57BL/6 * SJL J:210074 View
Tg(CMV-IgkvaD11)BCat/Tg(CMV-IgkvaD11)BCat involves: C57BL/6 * SJL J:212312 View
Tg(DMD-APP*)7Neve/0 involves: C57BL/6 * SJL J:105050, J:100978 View
Tg(DMD-APP*)18Neve/0 involves: C57BL/6 * SJL J:100978 View
Tg(Eno2-PSEN2)2348Ykk/0 involves: C57BL/6 * DBA/2 J:76934 View
Tg(Eno2-PSEN2*)1480Ykk/0 involves: C57BL/6 * DBA/2 J:76934 View
Tg(Mapt-MAPT*)#Hanr/0 involves: BALB/c * C57BL/6 J:137947 View
Tg(NEFL-APP)#Nalb/0 involves: C57BL/6 * C3H J:202532 View
Tg(PDGFB-APPInd)F17Plhn/0 C57BL/6-Tg(PDGFB-APPInd)F17Plhn J:107982 View
Tg(PDGFB-APPSwDutLon)46Lpr/0 involves: C57BL/6 * CBA J:86694 View
Tg(Hmgcr-PSEN1*M146L)#Lpr/0
Tg(PDGFB-APPSwDutLon)46Lpr/0
involves: C57BL/6 * CBA J:86694 View
Tg(PDGFB-APPSwInd)20Lms/0 involves: C57BL/6 * DBA/2 J:62290 View
Tg(Gfap-TGFB1)64Lms/0
Tg(PDGFB-APPSwInd)20Lms/0
involves: BALB/c * C57BL/6 * DBA/2 * SJL J:167619 View
Tg(PDGFB-APPSwInd)J9Lms/0 involves: C57BL/6 * DBA/2 J:62290 View
Tg(PDGFB-MAPT*V337M)1Atak/0 involves: C57BL/6 * SJL J:100964 View
Tg(Prnp-APP*)1Hmor/0 B6.Cg-Tg(Prnp-APP*)1Hmor J:159623 View
Tg(Prnp-App/APPswe)E1-2Dbo/0 B6.C3-Tg(Prnp-App/APPswe)E1-2Dbo J:109847 View
Tg(PRNP-APPSweInd)8Dwst/0 involves: C3H/HeJ * C57BL/6J J:166801 View
Tg(PRNP-APPSweInd)8Dwst/? involves: 129S6/SvEvTac J:113199 View
Npc1m1N/Npc1m1N
Tg(PRNP-APPSweInd)8Dwst/0
involves: BALB/c * C3H/HeJ * C57BL/6J J:188345 View
Tg(PRNP-APPSweInd)19959Dwst/0 involves: 129S6/SvEvTac * FVB/N J:177369 View
Tg(Prnp-ITM2B/APP695*40)1Emcg/0 involves: C3H * C57BL/6 J:101023 View
Tg(Prnp-ITM2B/APP695*42)A12Emcg/0 involves: C3H * C57BL/6 J:101023 View
Tg(Prnp-MAPT)7Vle/0 involves: C57BL/6 * SJL J:61052 View
Tg(Prnp-MAPT)43Vle/0 involves: C57BL/6 * DBA/2 J:61052 View
Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0 involves: C57BL/6 * DBA/2 * SJL * SW J:100965 View
Tg(Prnp-MAPT*P301S)PS19Vle/0 B6.Cg-Tg(Prnp-MAPT*P301S)PS19Vle J:174441 View
Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt+
Tg(PSEN1)5Dbo/0
involves: 129P2/OlaHsd J:180977 View
Tg(PSEN1dE9)S9Dbo/0 involves: C3H/HeJ * C57BL/6J J:104147 View
Tg(PSEN1H163R)G9Btla/0 involves: 129S4/SvJae J:58050 View
Tg(tetO-APPSwInd)102Dbo/0 involves: C3H/HeJ * C57BL/6J J:109829 View
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)102Dbo/0
involves: C3H/HeJ * C57BL/6 * CBA J:109829 View
Tg(Thy1-APP)3Somm/0 B6.Cg-Tg(Thy1-APP)3Somm J:80449 View
Tg(Thy1-APP)3Somm/0 involves: C57BL/6J * DBA/2 J:44603 View
Tg(Hmgcr-PSEN1*M146L)#Lpr/0
Tg(Thy1-APPSL)28Lpr/0
involves: C57BL/6 * CBA J:86694, J:99507 View
Tg(Thy1-APPSL)28Lpr/0 involves: C57BL/6 * CBA J:86694, J:99507 View
Psen1tm1Lpr/Psen1tm1Lpr
Tg(Thy1-APPSL)28Lpr/0
either: 129/Sv or (involves: 129/Sv * C57BL/6) J:93770 View
Psen1tm1Lpr/Psen1tm1Lpr
Tg(Thy1-APPSL)28Lpr/0
involves: 129 * C57BL/6 * CBA J:128106 View
Tg(Thy1-APPArc)M8Cagr/Tg(Thy1-APPArc)M8Cagr involves: C57BL/6 * CBA J:188191 View
Tg(Thy1-APPArc)M8Cagr/0 involves: C57BL/6 * CBA J:168288 View
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-BACE1)16Vln/0
involves: C57BL/6 * DBA * FVB/N J:93635 View
Tg(Thy1-APPLon)2Vln/0 involves: C57BL/6 * CBA * FVB/N J:86694 View
Tg(Thy1-APPLon)2Vln/0 involves: FVB/N J:93635 View
Tg(Hmgcr-PSEN1*M146L)#Lpr/0
Tg(Thy1-APPLon)2Vln/0
involves: C57BL/6 * CBA * FVB/N J:86694 View
Tg(Thy1-APPSw)10Jiri/0 involves: C3H * C57BL/6 J:128647 View
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0 C57BL/6-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr J:180835 View
Abcc1tm1Bor/Abcc1tm1Bor
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
FVB.Cg-Abcc1tm1Bor Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr J:178230 View
Tg(Thy1-APPSwDutIowa)BWevn/0 involves: C57BL/6 J:89848 View
Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Tg(Thy1-APPSwDutIowa)BWevn/?
involves: 129P2/OlaHsd * C57BL/6 J:136318 View
Tg(Thy1-APPSweAut)A7Tiwa/0 Not Specified J:204270 View
Tg(Thy1-APPSweLon)41Ema/0 involves: C57BL/6 * DBA/2 J:162842 View
Tg(Thy1-MAPT)1Vln/Tg(Thy1-MAPT)1Vln involves: FVB J:100972, J:100971 View
Tg(GSK3B*S9A)1Vln/0
Tg(Thy1-MAPT)1Vln/Tg(Thy1-MAPT)1Vln
involves: FVB J:100971 View
Tg(Thy1-MAPT)2Vln/Tg(Thy1-MAPT)2Vln involves: FVB J:100972, J:100971 View
Tg(GSK3B*S9A)1Vln/0
Tg(Thy1-MAPT)2Vln/Tg(Thy1-MAPT)2Vln
involves: FVB J:100971 View
Tg(Thy1-MAPT)22Schd/0 B6.Cg-Tg(Thy1-MAPT)22Schd J:111982 View
Tg(Thy1-MAPT)22Schd/0 involves: C57BL/6 * CBA J:197067 View
Tg(Thy1-MAPT*P301L)2Vln/Tg(Thy1-MAPT*P301L)2Vln FVB/N-Tg(Thy1-MAPT*P301L)2Vln J:96869 View
Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte involves: C57BL/6 * CBA J:155410 View
Additional Complex Models     Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)107Dbo/0
involves: C3H/HeJ * C57BL/6 * CBA J:109829 View
Tg(GFAP-tTA)#Hyms/0
Tg(tetO-HMOX1)#Hyms/0
involves: FVB J:190573 View
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-MAPT*P301L)#Kha/0
involves: FVB/N J:102973 View
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Tg(MAPT)8cPdav/?
involves: 129S4/SvJae * C57BL/6 * Swiss Webster J:84638, J:174270 View
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)18Dbo/0
involves: C3H/HeJ * C57BL/6 * CBA J:109829 View
Tg(Camk2a-tTA)1Mmay/?
Tg(tetO-MAPT*P301L)#Kha/?
involves: 129S6/SvEvTac * FVB/N J:99626 View
Tg(CMV-IghvaD11)DCat/0
Tg(CMV-IgkvaD11)ACat/0
involves: C57BL/6 * SJL J:62713 View
Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz/0
Tg(Thy1-MAPT)183Gotz/0
B6.Cg-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz Tg(Thy1-MAPT)183Gotz J:154968 View
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Tg(MAPT)8cPdav/0
B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J J:172426 View
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-MAPT*K280,-luc)#Eman/0
involves: C57BL/6 J:131379, J:169532 View
Disease phenotype
not observed
No similarity to the expected human disease phenotype was found.

        Allelic Composition Genetic Background Reference Phenotypes
NOT Models     Psen1tm1Psgh/Psen1tm1Psgh Not Specified J:66016 View
Mapttm1Noh/Mapttm1Noh involves: 129S4/SvJae J:19030 View
Apba2tm1Tsuz/Apba2tm1Tsuz C57BL/6-Apba2tm1Tsuz J:148481 View

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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory