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All mouse models of holoprosencephaly with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | holoprosencephaly 2 | Six3tm1Gco/Six3tm1Gco | involves: 129S1/Sv | J:81797 | View | |||
| holoprosencephaly 2 |
Six3tm3.1Gco/Six3+ Shhtm1Chg/Shh+ |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:140315 | View | ||||
| holoprosencephaly 2 |
Six3tm3Gco/Six3tm3Gco Foxg1tm1(cre)Skm/Foxg1+ |
involves: 129S1/Sv * C57BL/6 | J:140315 | View | ||||
| holoprosencephaly 2 | Six3tm4(cre/ERT2)Gco/Six3+ | involves: 129S1/Sv * C57BL/6 | J:140315 | View | ||||
| holoprosencephaly 3 |
Disp1icb/Disp1tm1Amc Shhtm1Amc/Shh+ |
involves: 129X1/SvJ * C57BL/6J | J:92058 | View | ||||
| holoprosencephaly 3 | Shhtm1Chg/Shhtm1Chg | involves: 129S1/Sv * 129X1/SvJ | J:35802 | View | ||||
| holoprosencephaly 3 | Shhtm1Chg/Shhtm1Chg | involves: C57BL/6 | J:89364 | View | ||||
| holoprosencephaly 5 | Zic2Ku/Zic2Ku | 129S.CAnNCrl(C3)-Zic2Ku | J:238567 | View | ||||
| holoprosencephaly 5 | Zic2Ku/Zic2Ku | C3.CAnNCrl-Zic2Ku | J:138862 | View | ||||
| holoprosencephaly 5 | Zic2tm1Jaru/Zic2tm1Jaru | involves: 129S4/SvJae * C57BL/6 | J:60644 | View | ||||
| holoprosencephaly 11 |
Boctm1Rsk/Boc+ Cdontm1Rsk/Cdontm1Rsk |
involves: 129/Sv * 129S6/SvEvTac | J:171767 | View | ||||
| holoprosencephaly 11 |
Boctm1Rsk/Boctm1Rsk Cdontm1Rsk/Cdontm1Rsk |
B6.129-Boctm1Rsk Cdontm1Rsk | J:171767 | View | ||||
| holoprosencephaly 11 |
Boctm1Rsk/Boctm1Rsk Cdontm1Rsk/Cdontm1Rsk |
involves: 129/Sv * 129S6/SvEvTac | J:171767 | View | ||||
| holoprosencephaly 11 |
Boctm2Rsk/Boc+ Cdontm1Rsk/Cdontm1Rsk |
involves: 129/Sv * 129S6/SvEvTac | J:171767 | View | ||||
| holoprosencephaly 11 |
Boctm2Rsk/Boctm2Rsk Cdontm1Rsk/Cdontm1Rsk |
B6.129-Boctm2Rsk Cdontm1Rsk | J:171767 | View | ||||
| holoprosencephaly 11 |
Boctm2Rsk/Boctm2Rsk Cdontm1Rsk/Cdontm1Rsk |
involves: 129/Sv * 129S6/SvEvTac | J:171767 | View | ||||
| holoprosencephaly 11 | Cdontm1Rsk/Cdontm1Rsk | involves: 129/Sv * C57BL/6 | J:82221 | View | ||||
| holoprosencephaly 11 | Cdontm2Rsk/Cdontm2Rsk | involves: 129/Sv * C57BL/6 | J:82221 | View | ||||
| | holoprosencephaly | NosipGt(OST138992)Lex/NosipGt(OST138992)Lex | B6.129S5-NosipGt(OST138992)Lex | J:245546 | View | |||
| holoprosencephaly | Pgap1m1Nisw/Pgap1m1Nisw | involves: C57BL/6J | J:187360 | View | ||||
| holoprosencephaly | Pignm1Nisw/Pignm1Nisw | involves: 129S1/SvImJ * C3H/HeJ * C57BL/6J | J:187360 | View | ||||
| Additional Complex Models | holoprosencephaly |
Chrdtm1Emdr/Chrdtm1Emdr Nodaltm1Rob/Nodal+ |
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ | J:161524 | View | |||
| holoprosencephaly |
Nogtm1Amc/Nogtm1Amc Smad3tm1Xfw/Smad3+ |
involves: 129/Sv * 129S1/Sv | J:161524 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | holoprosencephaly 4 | Tgif1tm1.1Caw/Tgif1tm1.1Caw | involves: C57BL/6 * FVB/N | J:97642 | View | |||