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All mouse models of bone remodeling disease with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | autosomal dominant hypophosphatemic rickets | Fgf23tm1.1Kew/Fgf23tm1.1Kew | B6.129-Fgf23tm1.1Kew | J:180061 | View | |||
| autosomal dominant hypophosphatemic rickets |
Fgf23tm1Blan/Fgf23tm1Blan PhexHyp/Y |
Not Specified | J:94041 | View | ||||
| autosomal dominant osteopetrosis 2 | Clcn7tm1.1Aros/Clcn7tm1.1Aros | involves: 129P2/OlaHsd * C57BL/6N | J:273179 | View | ||||
| autosomal dominant osteopetrosis 2 | Clcn7tm1.1Mawa/Clcn7+ | involves: C57BL/6J * C57BL/6N * CD-1 | J:254787 | View | ||||
| autosomal dominant osteopetrosis 2 | Clcn7tm1.1Mjec/Clcn7+ | involves: 129 * 129S/SvEv * C57BL/6 | J:203761 | View | ||||
| autosomal dominant osteopetrosis 2 | Clcn7tm1.1Mjec/Clcn7+ | involves: 129S/SvEv * C57BL/6 * DBA/2J | J:203761 | View | ||||
| autosomal dominant osteopetrosis 2 | Clcn7tm1.1Teti/Clcn7+ | involves: 129S2/SvPas * C57BL/6 | J:203761 | View | ||||
| autosomal dominant osteopetrosis 2 | Clcn7tm1.1Teti/Clcn7tm1.1Teti | involves: 129S2/SvPas * C57BL/6 | J:203761 | View | ||||
| autosomal dominant osteopetrosis 2 | Clcn7tm1.1Teti/Clcn7tm1.1Teti | involves: 129S2/SvPas * CD-1 | J:203761 | View | ||||
| autosomal recessive osteopetrosis 1 | Tcirg1oc/Tcirg1oc | B6C3Fe a/a-Tcirg1oc/J | J:61295 | View | ||||
| autosomal recessive osteopetrosis 1 | Tcirg1tm1Ypl/Tcirg1tm1Ypl | involves: 129S4/SvJae * C57BL/6J | J:58795 | View | ||||
| autosomal recessive osteopetrosis 2 | Tnfsf11gum/Tnfsf11gum | STOCK Tnfsf11gum/GrsrJ | J:223062 | View | ||||
| autosomal recessive osteopetrosis 2 | Tnfsf11tles/Tnfsf11tles | involves: 129S6/SvEvTac * C57BL/6J | J:179743 | View | ||||
| autosomal recessive osteopetrosis 2 | Tnfsf11tm1Ywc/Tnfsf11tm1Ywc | involves: 129P2/OlaHsd | J:233265 | View | ||||
| autosomal recessive osteopetrosis 3 | Car2n/Car2n | involves: C57BL/6J * DBA/2J | J:19268 | View | ||||
| autosomal recessive osteopetrosis 4 | Clcn7tm1Tjj/Clcn7tm1Tjj | involves: 129P2/OlaHsd * C57BL/6 | J:67273 | View | ||||
| autosomal recessive osteopetrosis 4 | Clcn7tm2Tjj/Clcn7tm2Tjj | involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:67273 | View | ||||
| autosomal recessive osteopetrosis 5 | Ostm1gl/Ostm1gl | GL/Le Edardl-J +/+ Ostm1gl/J | J:5561 | View | ||||
| autosomal recessive osteopetrosis 6 |
Ctsktm1(cre)Ska/Ctsk+ Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao |
involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj | J:236517 | View | ||||
| autosomal recessive osteopetrosis 6 | Plekhm1tm1.2Hzhao/Plekhm1tm1.2Hzhao | involves: 129S1/Sv * C57BL/6J | J:236517 | View | ||||
| autosomal recessive osteopetrosis 8 | Snx10em1Ael/Snx10em1Ael | involves: 129 * C57BL/6J * C57BL/6JOlaHsd | J:289051 | View | ||||
| autosomal recessive osteopetrosis 8 | Snx10em2Ael/Snx10em2Ael | involves: 129 * C57BL/6J * C57BL/6JOlaHsd | J:289051 | View | ||||
| craniotubular dysplasia Ikegawa type | Tmem53em1Ikeg/Tmem53em1Ikeg | Not Specified | J:306057 | View | ||||
| hereditary hypophosphatemic rickets with hypercalciuria | Slc34a1tm1Hten/Slc34a1tm1Hten | involves: 129S2/SvPas * C57BL/6J | J:47637 | View | ||||
| hereditary hypophosphatemic rickets with hypercalciuria |
Slc34a1tm1Hten/Slc34a1tm1Hten Slc34a3tm1Kimi/Slc34a3tm1Kimi |
B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten | J:152195 | View | ||||
| hereditary multiple exostoses |
Ext1tm1.1Vcs/Ext1tm1.1Vcs Tg(Col2a1-cre/ERT)KA3Smac/0 |
involves: 129S1/Sv * 129X1/SvJ * FVB/N | J:242977 | View | ||||
| hereditary multiple exostoses |
Ext1tm1.1Vcs/Ext1tm1.1Vcs Tg(Col2a1-rtTA,tetO-cre)22Pjro/0 |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL | J:157599 | View | ||||
| hereditary multiple exostoses |
Ext1tm1Vcs/Ext1tm1Vcs Tg(Col2a1-rtTA,tetO-cre)22Pjro/0 |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:157599 | View | ||||
| hereditary multiple exostoses |
Ext1tm1Yama/Ext1tm1Yama Acantm1(cre/ERT2)Crm/Acan+ |
involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6NCrl | J:242977 | View | ||||
| hereditary multiple exostoses |
Ext1tm1Yama/Ext1tm1Yama Tg(Col2a1-cre/ERT)KA3Smac/0 |
involves: 129S5/SvEvBrd * FVB/N | J:161395 | View | ||||
| osteopathia striata with cranial sclerosis |
Amer1tm1.1Nbar/Y Tg(Prrx1-cre)1Cjt/0 |
involves: 129S4/SvJae * C57BL/6 * SJL | J:173242 | View | ||||
| osteopathia striata with cranial sclerosis | Amer1tm1.2Nbar/Y | involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL | J:173242 | View | ||||
| osteoporosis | Pls3em2Bult/Pls3em2Bult | C57BL/6J-Pls3em2Bult/BultJ | J:341714 | View | ||||
| osteoporosis | Pls3em2Bult/Y | C57BL/6J-Pls3em2Bult/BultJ | J:341714 | View | ||||
| osteoporosis | Tg(APCS-Tnfsf11*)#aKhs/0 | C57BL/6J-Tg(APCS-Tnfsf11*)#aKhs | J:264357 | View | ||||
| Paget's disease of bone | Sqstm1tm1.1Sral/Sqstm1+ | involves: 129/Sv * 129P2/OlaHsd * C57BL/6 | J:173755 | View | ||||
| Paget's disease of bone | Sqstm1tm1.1Sral/Sqstm1tm1.1Sral | involves: 129/Sv * 129P2/OlaHsd * C57BL/6 | J:173755 | View | ||||
| Paget's disease of bone | Sqstm1tm1Keta/Sqstm1tm1Keta | involves: 129 * C57BL/6N | J:264183 | View | ||||
| Paget's disease of bone | Tnfrsf11atm1.1Sral/Tnfrsf11a+ | B6.129P2(Cg)-Tnfrsf11atm1.1Sral | J:312215 | View | ||||
| rickets | Cyp27b1tm1Dgo/Cyp27b1tm1Dgo | involves: 129S1/Sv * 129X1/SvJ * BALB/c | J:70030 | View | ||||
| rickets | Cyp27b1tm1Star/Cyp27b1tm1Star | involves: 129S1/Sv * 129X1/SvJ | J:71928, J:71937, J:78635, J:90983, J:90984 | View | ||||
| rickets |
Tg(VDR*L233S,luc)T807Pike/0 Vdrtm1Mbd/Vdrtm1Mbd |
involves: 129S4/SvJae * C57BL/6 | J:218709 | View | ||||
| rickets | Vdrtm1Mbd/Vdrtm1Mbd | involves: 129S4/SvJae | J:42815 | View | ||||
| rickets | Vdrtm1Mbd/Vdrtm1Mbd | involves: 129S4/SvJae * C57BL/6J | J:99866 | View | ||||
| rickets | Vdrtm1Ska/Vdrtm1Ska | involves: C57BL/6NCrlj * CBA/JNCrlj | J:42054, J:83237 | View | ||||
| sclerosteosis 1 | Sosttm1Paz/Sosttm1Paz | involves: 129/Sv * Black Swiss | J:213541 | View | ||||
| sclerosteosis 2 | Lrp4mdig-3J/Lrp4mdig-3J | B6.Cg-Lrp4mdig-3J/GrsrJ | J:224655 | View | ||||
| sclerosteosis 2 | Lrp4tm1.1Pg/Lrp4tm1.1Pg | involves: C57BL/6N | J:277372 | View | ||||
| X-linked dominant hypophosphatemic rickets |
Fgf23tm1Blan/Fgf23+ PhexHyp/Y |
Not Specified | J:94041 | View | ||||
| X-linked dominant hypophosphatemic rickets |
Fgf23tm1Sliu/Fgf23+ PhexHyp/Y |
involves: 129S/SvEv * C57BL/6 | J:110579 | View | ||||
| X-linked dominant hypophosphatemic rickets |
Fgf23tm1Sliu/Fgf23tm1Sliu PhexHyp/Y |
involves: 129S/SvEv * C57BL/6 | J:110579 | View | ||||
| X-linked dominant hypophosphatemic rickets | Gy/Y | involves: C3H/Sn * C57BL/6Ei | J:38621, J:88352 | View | ||||
| X-linked dominant hypophosphatemic rickets | PhexHyp-2J/Phex+ | C57BL/6-PhexHyp-2J/J | J:88352 | View | ||||
| X-linked dominant hypophosphatemic rickets | PhexHyp-2J/Y | C57BL/6-PhexHyp-2J/J | J:88352 | View | ||||
| X-linked dominant hypophosphatemic rickets | PhexHyp-Duk/Phex+ | involves: BALB/cAnBomUrd | J:88352 | View | ||||
| X-linked dominant hypophosphatemic rickets | PhexHyp-Duk/Y | involves: BALB/cAnBomUrd | J:88352 | View | ||||
| X-linked dominant hypophosphatemic rickets | PhexHyp/? | involves: C57BL/6J | J:99866 | View | ||||
| X-linked dominant hypophosphatemic rickets | PhexHyp/Phex+ | B6.Cg-PhexHyp/J | J:88352 | View | ||||
| X-linked dominant hypophosphatemic rickets | PhexHyp/Y | B6.Cg-PhexHyp/J | J:38621, J:67356, J:88352 | View | ||||
| X-linked dominant hypophosphatemic rickets | Phexm1Jrt/Phex+ | B6.129S1-PhexM1Jrt | J:196537 | View | ||||
| X-linked dominant hypophosphatemic rickets | Phexm1Jrt/Y | B6.129S1-PhexM1Jrt | J:196537 | View | ||||
| X-linked dominant hypophosphatemic rickets | PhexMhdabap012/PhexMhdabap012 | C3HeB/FeJ-PhexMhdabap012 | J:183993 | View | ||||
| X-linked dominant hypophosphatemic rickets | PhexMhdabap024/Phex+ | C3HeB/FeJ-PhexMhdabap024 | J:264682 | View | ||||
| X-linked dominant hypophosphatemic rickets | PhexMhdabap024/PhexMhdabap024 | C3HeB/FeJ-PhexMhdabap024 | J:183993 | View | ||||
| X-linked dominant hypophosphatemic rickets | PhexMhdabap024/Y | C3HeB/FeJ-PhexMhdabap024 | J:264682 | View | ||||
| X-linked dominant hypophosphatemic rickets | PhexPug/Y | involves: C57BL/6J | J:136463 | View | ||||
| X-linked dominant hypophosphatemic rickets | PhexSka1/Phex+ | C57BL/6-PhexSka1 | J:79953 | View | ||||
| X-linked dominant hypophosphatemic rickets | PhexSka1/Y | C57BL/6-PhexSka1 | J:79953 | View | ||||
| | autosomal recessive hypophosphatemic rickets | Dmp1tm1Mis/Dmp1tm1Mis | involves: 129S7/SvEvBrd * CD-1 | J:184352 | View | |||
| autosomal recessive osteopetrosis 1 | Ccdc154ntl/Ccdc154ntl | involves: 129S7/SvEvBrd * C57BL/6J | J:226596 | View | ||||
| bone remodeling disease | Idh2tm1Jwpk/Idh2tm1Jwpk | involves: 129S4/SvJae * C57BL/6 | J:272241 | View | ||||
| Camurati-Engelmann disease | Mitfmi-ew/Mitfmi-ew | involves: C57BL/6Bn * NAW | J:89821 | View | ||||
| craniometaphyseal dysplasia | Anktm1.1Ejr/Anktm1.1Ejr | B6.129-Anktm1.1Ejr | J:168526 | View | ||||
| hereditary multiple exostoses | Ext2tm1Werb/Ext2+ | involves: C57BL/6 | J:103125 | View | ||||
| osteopetrosis | Csf1op/Csf1op | B6C3Fe a/a-Csf1op/J | J:26978 | View | ||||
| osteopetrosis | Lrrk1tm1.1Smo/Lrrk1tm1.1Smo | involves: 129S/Sv | J:208677 | View | ||||
| osteopetrosis | MitfMi-Or/MitfMi-Or | involves: 101/Rl * C3H/Rl | J:30149 | View | ||||
| osteoporosis | Ciitatm1Wrth/Ciitatm1Wrth | involves: 129P2/OlaHsd * C57BL/6 | J:233241 | View | ||||
| osteoporosis | Id4tm1Fsky/Id4tm1Fsky | involves: 129P2/OlaHsd | J:162236 | View | ||||
| osteoporosis | Ifngr1tm1Agt/Ifngr1tm1Agt | B6.129S7-Ifngr1tm1Agt/J | J:233116 | View | ||||
| osteoporosis | Irak3tm1Flv/Irak3tm1Flv | involves: 129S1/Sv * C57BL/6 | J:98035 | View | ||||
| osteoporosis | Ly6atm1Pmf/Ly6atm1Pmf | C.129P2-Ly6atm1Pmf | J:83409 | View | ||||
| osteoporosis | Terctm1Rdp/Terctm1Rdp | B6J.Cg-Terctm1Rdp | J:213181 | View | ||||
| osteoporosis |
Terctm1Rdp/Terctm1Rdp Wrntm1Lgu/Wrntm1Lgu |
involves: 129/Sv * BALB/c * C57BL/6 * SLJ | J:213181 | View | ||||
| osteoporosis | Tnfrsf11btm1Khs/Tnfrsf11btm1Khs | involves: 129P2/OlaHsd * C57BL/6 | J:48325 | View | ||||
| osteoporosis | Vdrtm1Ska/Vdrtm1Ska | involves: C57BL/6NCrlj * CBA/JNCrlj | J:83237 | View | ||||
| Paget's disease of bone | Inpp5dtm1Rkh/Inpp5dtm1Rkh | involves: 129S1/Sv * 129X1/SvJ | J:78771 | View | ||||
| rickets |
Fam20ctm1.1Cqi/Fam20ctm1.1Cqi Edil3Tg(Sox2-cre)1Amc/Edil3+ |
involves: 129S6/SvEvTac * C57BL/6 * CBA | J:185208 | View | ||||
| SOST-related sclerosing bone dysplasia | Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg | involves: C57BL/6NTac | J:188586 | View | ||||
| Transgenes and Other Mutations | autosomal dominant hypophosphatemic rickets | Tg(APOE-FGF23*R176Q)#Ack/0 | involves: C57BL/6J * CBA | J:93981 | View | |||
| autosomal recessive hypophosphatemic rickets | Tg(APOE-FGF23*R176Q)#Ack/0 | involves: C57BL/6J * CBA | J:192371 | View | ||||
| osteoporosis | Tg(CD4-CIITA)357Ccum/? | involves: C57BL/6 * C57BL/6J * SJL | J:233241 | View | ||||
| osteoporosis | Tg(TNFSF11)5519Edou/0 | involves: C57BL/6J * CBA/J | J:233240 | View | ||||
| SOST-related sclerosing bone dysplasia | Rr20tm1.1Vlcg/Rr20tm1.1Vlcg | involves: 129S6/SvEvTac * C57BL/6NTac | J:188586 | View | ||||
| SOST-related sclerosing bone dysplasia | Tg(RP11-209M4)AGglo/0 | FVB-Tg(RP11-209M4)4Gglo | J:99965 | View | ||||
| SOST-related sclerosing bone dysplasia | Tg(RP11-209M4)AGglo/Tg(RP11-209M4)AGglo | FVB-Tg(RP11-209M4)4Gglo | J:99965 | View | ||||
| X-linked dominant hypophosphatemic rickets | Tg(APOE-FGF23*R176Q)#Ack/0 | involves: C57BL/6J * CBA | J:93981 | View | ||||
| X-linked dominant hypophosphatemic rickets | Tg(Col1a1-FGF2*,-Sapphire)203Mmh/Tg(Col1a1-FGF2*,-Sapphire)203Mmh | involves: FVB/N | J:240777 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | Paget's disease of bone | Sqstm1tm1Jjw/Sqstm1tm1Jjw | involves: 129 * C57BL/6 | J:141179 | View | |||