Human Disease and Mouse Model Detail

Human Disease

Noonan Syndrome 1; NS1
OMIM ID: 163950

Synonyms

Female Pseudo-Turner Syndrome; Male Turner Syndrome; Noonan Syndrome

View all models

View ALL (4) mouse models for this human disease.

Genes and
mouse models

Mutations in human and/or mouse homologs are associated with this disease

*Gene is associated with the disease in this species
Mouse Homologs	Human Homologs	Mouse Models	Mouse : Human Homology Class
Ptpn11*	PTPN11*	View 1 model	1:1 Homology

Transgenes and
other genome features

Transgenes and other genome features developed in mice to model this disease.

	Transgenes and Other Genome Features	Mouse Models
	Tg(CAG-cat,-Ptpn11*Q97R)1Rbns	View 2 models
	Tg(Myh7-Ptpn11*Q79R)11Rbns	View 1 model

Allelic Composition	Genetic Background	Reference	Phenotypes
Ptpn11tm1Bgn/Ptpn11⁺	involves: 129S4/SvJae * C57BL/6J	J:91609	View

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0 Tg(Tek-cre)12Flv/0	involves: C3H * C57BL/6 * FVB/N	J:142212	View
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0 Tg(Wnt1-cre)11Rth/0	involves: C57BL/6J * CBA/J * FVB/N	J:153094	View

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Myh7-Ptpn11*Q79R)11Rbns/0	FVB.Cg-Tg(Myh7-Ptpn11*Q79R)11Rbns	J:123963	View

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 05/22/2013 MGI 5.13