Human Disease and Mouse Model Detail

Human Disease

Huntington Disease; HD
OMIM ID: 143100

Synonyms

Huntington Chorea

View all models

View ALL (43) mouse models for this human disease.

Genes and
mouse models

Mutations in human and/or mouse homologs are associated with this disease

*Gene is associated with the disease in this species
Mouse Homologs	Human Homologs	Mouse Models	Mouse : Human Homology Class
Htt*	HTT*	View 16 models	1:1 Homology
Drd1a*	DRD1	View 1 model	1:1 Homology
Zdhhc13*	ZDHHC13	View 1 model	1:1 Homology
Zdhhc17*	ZDHHC17	View 1 model	1:1 Homology

Transgenes and
other genome features

Transgenes and other genome features developed in mice to model this disease.

	Transgenes and Other Genome Features	Mouse Models
	Tg(GFAP-HTT*160Q)1Xjl	View 1 model
	Tg(GFAP-HTT*160Q)31Xjl	View 1 model
	Tg(HD82Gln)81Dbo	View 3 models
	Tg(HD)63Aron	View 1 model
	Tg(HDexon1)61Gpb	View 1 model
	Tg(HDexon1)62Gpb	View 3 models
	Tg(HTT*97Q)IXwy	View 1 model
	Tg(HTT*)1Xwy	View 1 model
	Tg(HTT*/EGFP)150Nn	View 1 model
	Tg(HTT*/EGFP)190Nn	View 1 model
	Tg(Ppp1r1b-HTT*)1Meeh	View 1 model
	Tg(Prnp-HTT*82Q)52Caro	View 1 model
	Tg(Prnp-HTT*82Q,KRT14-EGFP)C63Dbo	View 1 model
	Tg(YAC72)2511Hay	View 2 models
	Tg(YAC128)53Hay	View 1 model
	Tg(YAC128)55Hay	View 2 models

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Gene: Htt

Allelic Composition	Genetic Background	Reference	Phenotypes
Htttm1Mfc/Htttm1Mfc	involves: 129S1/Sv * C57BL/6	J:85298, J:141673	View
Htttm2Detl/Htttm2Detl	involves: 129P2/OlaHsd * C57BL/6J	J:123681	View
Htttm1Detl/Htttm1Detl	involves: 129P2/OlaHsd * C57BL/6J	J:67074	View
Htttm4Mem/Htttm4Mem	involves: 129S1/Sv * 129X1/SvJ * CD-1	J:60937, J:99425, J:111237	View
Htttm5Mem/Htttm5Mem	involves: 129S1/Sv * 129X1/SvJ * CD-1	J:60937, J:99425, J:111237	View
Htttm1.1Pfs/Htt⁺	involves: 129S4/SvJae * C57BL/6	J:54906	View
Htttm2.1Pfs/Htt⁺	involves: 129X1/SvJ * C57BL/6	J:54906	View
Htttm2Msl/Htttm2Msl	involves: 129S1/Sv * C57BL/6J	J:76018, J:79137	View
Htttm1.1Tna/Htttm1.1Tna	involves: 129P2/OlaHsd * C57BL/6J	J:76017	View
Htttm1Detl/Htt⁺	involves: 129P2/OlaHsd * C57BL/6J	J:67074	View
Htttm1Hay/Htt⁺	involves: C57BL/6J	J:25941	View
Htttm1Szi/Htttm2Szi Tg(Camk2a-cre)2Szi/0	involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA	J:65520	View
Htttm4Mem/Htt⁺	involves: 129S1/Sv * 129X1/SvJ * CD-1	J:60937	View
Htttm1.1Tna/Htt⁺	involves: 129P2/OlaHsd * C57BL/6J	J:76017	View
Htttm1Szi/Htttm2Szi Tg(Camk2a-cre)1Szi/0	involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA	J:65520	View
Htttm5Mem/Htt⁺	involves: 129S1/Sv * 129X1/SvJ * CD-1	J:60937	View

NOT Models
No similarity to the expected human disease phenotype was found.

Allelic Composition	Genetic Background	Reference	Phenotypes
Htttm1Szi/Htttm1Szi	either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * MF1)	J:29267	View
Htttm1Mem/Htttm1Mem	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1	J:27183	View
Htttm1Hay/Htttm1Hay	involves: C57BL/6J	J:25941	View
Htttm7Mem/Htttm7Mem	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1	J:44391	View
Htttm3Mem/Htttm3Mem	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1	J:44391	View
Htttm2Mem/Htttm2Mem	involves: 129S1/Sv * 129X1/SvJ * CD-1	J:99425	View
Htttm3Mem/Htttm3Mem	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	J:99425	View
Htttm6Mem/Htttm8Mem	involves: 129S1/Sv * 129X1/SvJ * Swiss Webster	J:72915	View
Htttm1Mem/Htttm7Mem	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1	J:44391	View

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Gene: Drd1a

Allelic Composition	Genetic Background	Reference	Phenotypes
Drd1atm2Jcd/Drd1a⁺ Tg(Camk2a-cre)2Gsc/0	involves: 129S4/SvJae * FVB/N	J:120070	View

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Gene: Zdhhc13

Allelic Composition	Genetic Background	Reference	Phenotypes
Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi	FVB.129P2-Zdhhc13Gt(AC0492)Wtsi	J:191129	View

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Gene: Zdhhc17

Allelic Composition	Genetic Background	Reference	Phenotypes
Zdhhc17Gt(RRJ233)Byg/Zdhhc17Gt(RRJ233)Byg	FVB.129P2-Zdhhc17Gt(RRJ233)Byg	J:175800	View

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Transgene: Tg(GFAP-HTT*160Q)1Xjl

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(GFAP-HTT*160Q)1Xjl/0	either: (involves: FVB/NCrl) or (involves: C3H * C57BL/6 * FVB/NCrl)	J:156460	View

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Transgene: Tg(GFAP-HTT*160Q)31Xjl

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(GFAP-HTT*160Q)31Xjl/0	either: (involves: FVB/NCrl) or (involves: C3H * C57BL/6 * FVB/NCrl)	J:156460	View

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Transgene: Tg(HD82Gln)81Dbo

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(HD82Gln)81Dbo/0	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * CD-1	J:172874	View
Tg(HD82Gln)81Dbo/0	involves: C3H/HeJ * C57BL/6	J:53797	View
Cnr1tm1Map/Cnr1tm1Map Tg(HD82Gln)81Dbo/0	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * CD-1	J:172874	View

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Transgene: Tg(HD)63Aron

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(HD)63Aron/?	involves: C57BL/6 * SJL	J:72772	View

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Transgene: Tg(HDexon1)61Gpb

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(HDexon1)61Gpb/?	involves: C57BL/6 * CBA	J:42085	View

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Transgene: Tg(HDexon1)62Gpb

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(HDexon1)62Gpb/0	B6CBA-Tg(HDexon1)62Gpb/1J	J:99425, J:111237	View
Tg(HDexon1)62Gpb/0	involves: C57BL/6 * CBA	J:42085	View
Tg(HDexon1)62Gpb/0	involves: C57BL/6J * CBA/J	J:36689	View

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Transgene: Tg(HTT*97Q)IXwy

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(HTT*97Q)IXwy/0	FVB-Tg(HTT*97Q)IXwy	J:137345	View

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Transgene: Tg(HTT*)1Xwy

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(HTT*)1Xwy/0	FVB-Tg(HTT*)1Xwy	J:157723	View

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Transgene: Tg(HTT*/EGFP)150Nn

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(HTT*/EGFP)150Nn/0	involves: C57BL/6 * DBA/2	J:174269	View

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Transgene: Tg(HTT*/EGFP)190Nn

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(HTT*/EGFP)190Nn/0	involves: C57BL/6 * DBA/2	J:174269	View

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Transgene: Tg(Ppp1r1b-HTT*)1Meeh

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Ppp1r1b-HTT*)1Meeh/0	C57BL/6J-Tg(Ppp1r1b-HTT*)1Meeh	J:139807	View

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Transgene: Tg(Prnp-HTT*82Q)52Caro

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Prnp-HTT*82Q)52Caro/0	involves: C3H * C57BL/6	J:179364	View

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Transgene: Tg(Prnp-HTT*82Q,KRT14-EGFP)C63Dbo

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Prnp-HTT*82Q,KRT14-EGFP)C63Dbo/0	Not Specified	J:173756	View

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Transgene: Tg(YAC72)2511Hay

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(YAC72)2511Hay/Tg(YAC72)2511Hay	FVB/N-Tg(YAC72)2511Hay	J:105728	View
Tg(YAC72)2511Hay/?	involves: FVB/N	J:55405	View

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Transgene: Tg(YAC128)53Hay

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(YAC128)53Hay/0	FVB/N-Tg(YAC128)53Hay	J:84453, J:105723, J:111237	View

Mouse Models

Human Disease Modeled: Huntington Disease; HD
Associated Mouse Transgene: Tg(YAC128)55Hay

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(YAC128)55Hay/Tg(YAC128)55Hay	FVB/N-Tg(YAC128)55Hay	J:105723, J:105728	View
Tg(YAC128)55Hay/0	FVB/N-Tg(YAC128)55Hay	J:105723	View

Mouse Models