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Human Disease and Mouse Model Detail
Human Disease Hepatocellular Carcinoma
OMIM ID: 114550
Human Phenotype Ontology associations
Synonyms Cancer, Hepatocellular; HCC; Liver Cancer; Liver Cell Carcinoma; LCC
View all models View ALL (47) mouse models for this human disease.
Genes and
mouse models
Mutations in human and/or mouse homologs are associated with this disease

      *Disease is associated/modeled with this Gene or a homolog. More...
      Human Homologs Mouse Homologs Mouse Models Homology Source
     APC* Apc* View 1 model HomoloGene and HGNC
     ABCB4 Abcb4* View 1 model HomoloGene and HGNC
CDKN1A Cdkn1a* View 4 models HomoloGene
FOXM1 Foxm1* View 1 model HomoloGene
GNMT Gnmt* View 1 model HomoloGene
IQGAP2 Iqgap2* View 1 model HomoloGene and HGNC
MCM9 Mcm9* View 3 models HomoloGene and HGNC
MYC Myc* View 9 models HomoloGene
NFE2L1 Nfe2l1* View 1 model HomoloGene
NR1H4 Nr1h4* View 2 models HomoloGene and HGNC
PTEN Pten* View 3 models HomoloGene and HGNC
TXNIP Txnip* View 3 models HomoloGene and HGNC
UACA Uaca* View 1 model HomoloGene
     AXIN1* Axin1   HomoloGene
CASP8* Casp8   HomoloGene and HGNC
CTNNB1* Ctnnb1   HomoloGene and HGNC
IGF2R* Igf2r   HomoloGene and HGNC
MET* Met View 1 model HomoloGene
PDGFRL* Pdgfrl   HomoloGene and HGNC
PIK3CA* Pik3ca   HomoloGene
TP53* Trp53   HomoloGene and HGNC
Transgenes and
other genome features
Transgenes and other genome features developed in mice to model this disease.

     Transgenes and Other Genome Features Mouse Models
  Tg(Alb1HBV)44Bri View 1 model
  Tg(Alb-E2F1)8Sst View 2 models
  Tg(Alb-HBx)A112Tfts View 1 model
  Tg(Alb-HRAS*G12V)28Yu View 1 model
  Tg(Alb-PDGFC)#Jcam View 1 model
  Tg(Alb-TAg)1Gjh View 1 model
  Tg(Alb-TAg)#Arnd View 1 model
  Tg(HBVX*,-Myc)#Skp View 1 model
  Tg(HBx)3Yu View 1 model
  Tg(Mup3-Plau)350-2Eps View 1 model
  Tg(Myl2-FGF19)1Dfre View 1 model
  Tg(Pklr-Myc)73Ak View 4 models
  Tg(SERPINC1-SV40)A1Pbr View 2 models
  Tg(SERPINC1-SV40)BPbr View 1 model
  Tg(tetO-MET)23Rwng View 1 model
  Tg(tetO-MYC)36aBop View 2 models
References Disease References using Mouse Models (57)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.05
The Jackson Laboratory