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Human Disease and Mouse Model Detail
Human Disease Amyotrophic Lateral Sclerosis 1; ALS1
OMIM ID: 105400
Human Phenotype Ontology associations
Synonyms Amyotrophic Lateral Sclerosis; Amyotrophic Lateral Sclerosis 1, Familial; FALS
View all models View ALL (51) mouse models for this human disease.
Genes and
mouse models
Mutations in human and/or mouse homologs are associated with this disease

      *Disease is associated/modeled with this Gene or a homolog. More...
      Human Homologs Mouse Homologs Mouse Models Homology Source
     SOD1* Sod1* View 38 models HomoloGene and HGNC
     SNCG Sncg* View 1 model HomoloGene and HGNC
SOD2 Sod2* View 1 model HomoloGene and HGNC
VEGFA Vegfa* View 1 model HomoloGene and HGNC
VPS54 Vps54* View 1 model HomoloGene and HGNC
     DCTN1* Dctn1 View 1 model HomoloGene and HGNC
NEFH* Nefh View 4 models HomoloGene and HGNC
PRPH* Prph   HomoloGene and HGNC
Transgenes and
other genome features
Transgenes and other genome features developed in mice to model this disease.

     Transgenes and Other Genome Features Mouse Models
  Tg(Myl1-SOD1*G93A)#Amu View 1 model
  Tg(NEFH)200Jpj View 2 models
  Tg(NFH)120Jpj View 2 models
  Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo View 1 model
  Tg(SOD1*)125Dbo View 1 model
  Tg(SOD1*)D-14Dbo View 2 models
  Tg(SOD1*)DF7Yaw View 2 models
  Tg(SOD1*G37R)1Dwc View 2 models
  Tg(SOD1*G37R)9Dpr View 1 model
  Tg(SOD1*G37R)29Dpr View 1 model
  Tg(SOD1*G37R)42Dpr View 1 model
  Tg(SOD1*G37R)106Dpr View 1 model
  Tg(SOD1*G85R)74Dwc View 1 model
  Tg(SOD1*G85R)148Dwc View 1 model
  Tg(SOD1*G85R)#Roos View 2 models
  Tg(SOD1*G85R/EYFP)641Alho View 1 model
  Tg(SOD1*G85R/EYFP)737Alho View 1 model
  Tg(Sod1*G86R)M1Jwg View 1 model
  Tg(SOD1*G93A)1Gur View 6 models
  Tg(SOD1*G93A)2Gur View 1 model
  Tg(SOD1*G93A)dl1Gur View 2 models
  Tg(SOD1*G127X)716Mrkl View 1 model
  Tg(SOD1*H46R)#Maw View 1 model
  Tg(SOD1*H46R)IAra View 1 model
  Tg(SOD1*H46R)LAra View 1 model
  Tg(SOD1*H46R*H48Q)58Dbo View 1 model
  Tg(SOD1*H46R*H48Q)139Dbo View 1 model
  Tg(SOD1*L126Z)45Dbo View 1 model
  Tg(SOD1*L126Z)#Deng View 2 models
  Tg(Thy1-DCTN1*G59S)M2Pcw View 1 model
  Tg(Thy1-Sncg)HvP36Putt View 1 model
  Tg(Thy1-SOD1*G93A)T3Hgrd View 2 models
References Disease References using Mouse Models (152)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory