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Human Disease and Mouse Model Detail
Human Disease Alzheimer Disease; AD
OMIM ID: 104300
Synonyms Alzheimer Disease
View all models View ALL (148) mouse models for this human disease.
Genes and
mouse models
Mutations in human and/or mouse homologs are associated with this disease

      *Disease is associated/modeled with this Gene or a homolog. More...
      Human Homologs Mouse Homologs Mouse Models Homology Source
     APP* App* View 103 models HomoloGene and HGNC
PLAU* Plau* View 1 model HomoloGene and HGNC
     CAV1 Cav1* View 1 model HomoloGene and HGNC
LRP1 Lrp1* View 2 models HomoloGene
MME Mme* View 1 model HomoloGene and HGNC
PIN1 Pin1* View 2 models HomoloGene and HGNC
PLCB1 Plcb1* View 1 model HomoloGene
PSEN1 Psen1* View 43 models HomoloGene and HGNC
TRIB2 Trib2* View 2 models HomoloGene
     A2M* A2m   HomoloGene and HGNC
ACE* Ace   HomoloGene
APBB2* Apbb2   HomoloGene
BLMH* Blmh   HomoloGene
HFE* Hfe   HomoloGene
MPO* Mpo   HomoloGene
NOS3* Nos3   HomoloGene and HGNC
PAXIP1* Paxip1   HGNC
SORL1* Sorl1 View 1 model HomoloGene and HGNC
Transgenes and
other genome features
Transgenes and other genome features developed in mice to model this disease.

     Transgenes and Other Genome Features Mouse Models
  Tg(ACTB-APP*V717F)1Colm View 1 model
  Tg(APP695)3Dbo View 8 models
  Tg(APP)8.9Btla View 1 model
  Tg(APPSw)40Btla View 2 models
  Tg(APPSWE)2576Kha View 12 models
  Tg(APPswe,PSEN1dE9)85Dbo View 4 models
  Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas View 6 models
  Tg(APPSwLon)96Btla View 1 model
  Tg(APPV717F)109Ili View 8 models
  Tg(Camk2a-App*,-Apbb1)25Spim View 1 model
  Tg(CMV-IgkvaD11)BCat View 2 models
  Tg(DMD-APP*)7Neve View 1 model
  Tg(DMD-APP*)18Neve View 1 model
  Tg(Eno2-APP*Ind)#Kakiz View 1 model
  Tg(Eno2-PSEN2)2348Ykk View 1 model
  Tg(Eno2-PSEN2*)1480Ykk View 1 model
  Tg(Mapt-MAPT*)#Hanr View 1 model
  Tg(NEFL-APP)#Nalb View 1 model
  Tg(PDGFB-APPInd)F17Plhn View 1 model
  Tg(PDGFB-APPSwDutLon)46Lpr View 2 models
  Tg(PDGFB-APPSwInd)20Lms View 2 models
  Tg(PDGFB-APPSwInd)J9Lms View 1 model
  Tg(PDGFB-MAPT*V337M)1Atak View 1 model
  Tg(Prnp-APP*)1Hmor View 1 model
  Tg(Prnp-App/APPswe)E1-2Dbo View 1 model
  Tg(PRNP-APPSweInd)8Dwst View 3 models
  Tg(PRNP-APPSweInd)19959Dwst View 1 model
  Tg(Prnp-ITM2B/APP695*40)1Emcg View 1 model
  Tg(Prnp-ITM2B/APP695*42)A12Emcg View 1 model
  Tg(Prnp-MAPT)7Vle View 1 model
  Tg(Prnp-MAPT)43Vle View 1 model
  Tg(Prnp-MAPT*P301L)JNPL3Hlmc View 2 models
  Tg(Prnp-MAPT*P301S)PS19Vle View 3 models
  Tg(PSEN1dE9)S9Dbo View 4 models
  Tg(PSEN1H163R)G9Btla View 1 model
  Tg(tetO-APPSwInd)18Dbo View 1 model
  Tg(tetO-APPSwInd)102Dbo View 2 models
  Tg(tetO-APPSwInd)107Dbo View 1 model
  Tg(tetO-CDK5R1/GFP)337Lht View 1 model
  Tg(tetO-HMOX1)#Hyms View 1 model
  Tg(tetO-MAPT*K280,-luc)#Eman View 1 model
  Tg(tetO-MAPT*P301L)#Kha View 2 models
  Tg(Thy1-APP)3Somm View 2 models
  Tg(Thy1-APPSL)28Lpr View 4 models
  Tg(Thy1-APPArc)M8Cagr View 2 models
  Tg(Thy1-APPLon)2Vln View 4 models
  Tg(Thy1-APPSw)10Jiri View 3 models
  Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr View 2 models
  Tg(Thy1-APPSwDutIowa)BWevn View 3 models
  Tg(Thy1-APPSweAut)A7Tiwa View 1 model
  Tg(Thy1-APPSweLon)41Ema View 1 model
  Tg(Thy1-MAPT)1Vln View 2 models
  Tg(Thy1-MAPT)2Vln View 2 models
  Tg(Thy1-MAPT)22Schd View 2 models
  Tg(Thy1-MAPT*P301L)2Vln View 1 model
  Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte View 1 model
References Disease References using Mouse Models (417)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.0
The Jackson Laboratory