progressive multifocal leukoencephalopathy (DOID:643)
Alliance: disease page
Synonyms: PML
Alt IDs: ICD10CM:A81.2, ICD9CM:046.3, MESH:D007968, NCI:C26815, UMLS_CUI:C0023524
Definition: A viral infectious disease that involves reactivation of JC polyomavirus in immune-compromised individuals which causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain. The symptoms include hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment and coma.