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Human Disease and Mouse Model Detail
Human Disease Diabetes Mellitus, Noninsulin-Dependent; NIDDM
OMIM ID: 125853
Synonyms Diabetes Mellitus, Noninsulin-Dependent; Diabetes Mellitus, Type II; T2D; Noninsulin-Dependent Diabetes Mellitus
View all models View ALL (38) mouse models for this human disease.
Genes and
mouse models
Mutations in human and/or mouse homologs are associated with this disease

      *Gene is associated with the disease in this species
      Mouse Homologs Human Homologs Mouse Models Mouse : Human
Homology Class
     Akt2* AKT2* View 1 model 1:1 Homology
Cdkal1* CDKAL1* View 1 model 1:1 Homology
Gck* GCK* View 2 models 1:1 Homology
Hmga1*, Hmga1-rs1 HMGA1* View 2 models 2:1 Homology
Hnf1a* HNF1A* View 1 model 1:1 Homology
Irs1* IRS1* View 3 models 1:1 Homology
Irs2* IRS2* View 4 models 1:1 Homology
     a* View 1 model
Ar* AR View 1 model 1:1 Homology
Ctf1* CTF1 View 1 model 1:1 Homology
Cyb5r4* CYB5R4 View 1 model 1:1 Homology
Fem1b* FEM1B View 1 model 1:1 Homology
Htr2c* HTR2C View 1 model 1:1 Homology
Ins2* INS View 1 model 1:1 Homology
Lep* LEP View 1 model 1:1 Homology
Lepr* LEPR View 5 models 1:1 Homology
Mafa* MAFA View 1 model 1:1 Homology
Phox2a* PHOX2A View 2 models 1:1 Homology
Ppp1r3a* PPP1R3A View 1 model 1:1 Homology
Ppp1r3c* PPP1R3C View 1 model 1:1 Homology
Slc2a2* SLC2A2 View 1 model 1:1 Homology
Slc2a4* SLC2A4 View 1 model 1:1 Homology
     Abcc8 ABCC8*   1:1 Homology
Enpp1 ENPP1*   1:1 Homology
Gcgr GCGR*   1:1 Homology
Gpd2 GPD2*   1:1 Homology
Hnf1b HNF1B*   1:1 Homology
Hnf4a HNF4A*   1:1 Homology
Igf2bp2 IGF2BP2*   1:1 Homology
Il6 IL6*   1:1 Homology
Kcnj11 KCNJ11*   1:1 Homology
Lipc LIPC*   1:1 Homology
Mapk8ip1 MAPK8IP1*   1:1 Homology
Mtnr1b MTNR1B*   1:1 Homology
Neurod1 NEUROD1*   1:1 Homology
Pax4 PAX4*   1:1 Homology
Pdx1 PDX1* View 1 model 1:1 Homology
Pparg PPARG*   1:1 Homology
Ptpn1 PTPN1*   1:1 Homology
Retn RETN*   1:1 Homology
Slc30a8 SLC30A8*   1:1 Homology
Tcf7l2 TCF7L2*   1:1 Homology
Wfs1 WFS1*   1:1 Homology
Transgenes and
other genome features
Transgenes and other genome features developed in mice to model this disease.

     Transgenes and Other Genome Features Mouse Models
  Tg(aP2-SREBF1c)9884Reh View 1 model
  Tg(Ckm-IGF1R*K1003R)1Dlr View 1 model
  Tg(UcpDta)1Kz View 2 models
  Timo View 1 model
References Disease References using Mouse Models (67)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory